Results 51 to 60 of about 486,384 (263)
Frontiers in Virtual RealityObjectiveThe present study is aimed to elaborate and determinate the content and face validity of a virtual reality program attending the perspective of children.
Imanol Ceberio +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
JISAE (Journal of Indonesian Student Assessment and Evaluation)This study aims to develop and validate a high-order thinking skills (HOTS)-based multiple-choice instrument to assess citizen participation in consumer education.
Putu Diah Ari Kusumadewi +3 more
doaj +1 more source
Patient Preference and Adherence, 2021 Sonal Ghura Mansukhani,1 Elizabeth A MacLean,2 Laura L Manzey,2 Carl J Possidente,2 Joseph C Cappelleri,2 Linda S Deal2 1Patient Centered Outcomes Research, Evidera, Waltham, Massachusetts, USA; 2Medical Outcomes Specialists (EAM, LLM, CJP); Patient ...
Mansukhani SG +5 more
doaj
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Journal of Medical Education Development, 2018 Development and assessment of measurement tools are important stages in the research processes regarding social, educational, and medical sciences, which mainly focus on the measurement of characteristics, qualitative variables, and abstract variables ...
Mohammad Masoud Vakili, Nasrin Jahangiri
doaj
The Meaning of Content Validity [PDF]
Applied Psychological Measurement, 1983 The ways in which test specialists have defined content validity are reviewed and evaluated in order to determine the manner in which this validity might best be viewed. These specialists have differed in their def initions, variously associating content validity with (1) the sampling adequacy of test content, (2) the sam pling adequacy of test ...
openaire +2 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source