Results 191 to 200 of about 6,202,666 (342)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Beyond the baseline: mapping the context-specific regulatory landscape of disease. [PDF]

Trends Genet
Gilad Y, Battle A.
europepmc   +1 more source

Formalization of System Engineering Processes (Proposal of a method to adapt generic processes to different application contexts)

, 2007
Samuel Rochet, BARON, Claude
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Effectiveness of coordination in humanitarian water, sanitation, and hygiene (WASH) response: evidence from a mixed-methods evaluation of outcomes and outputs across five national coordination platforms. [PDF]

Confl Health
Nguyen D, Heylen C, Cunningham C, Salagnac A, Ramos M, Lantagne D.   +5 more
europepmc   +1 more source

The moral status of embryonic stem cell research in the South African context

, 2007
Nico Nortjé
openalex   +1 more source

Context, interest relativity and the sorites [PDF]

, 2003
J. Stanley
openalex   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Learning, sleep replay and consolidation of contextual fear memories: A neural network model. [PDF]

PLoS Comput Biol
Werne L, Chadwick A, Seriès P.
europepmc   +1 more source

An investigation into the lived experience of project leaders in a loosely-coupled transient project context

, 2015
Christopher Cullen
openalex   +1 more source