Results 91 to 100 of about 384,374 (268)

Change-making in a (post)apartheid city: An auto-ethnographical essay

HTS Teologiese Studies/Theological Studies, 2018
We reflect on living and doing ministry in a (post)apartheid South African city, negotiating ongoing demographic and sociopolitical transitions and discerning appropriate faith responses.
Stephan F. de Beer, Wilna de Beer
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

25th Annual Forum of Young Legal Historians: Introduction

Rechtsgeschichte - Legal History, 2021
Wouter De Rycke, Cornelis Marinus in ’t Veld, Maxime Jottrand, Romain Landmeters, Stephanie Plasschaert   +4 more
doaj   +2 more sources

The parable of the Feast (Lk 14:16b–23): Breaking down boundaries and discerning a theological–spatial justice agenda

HTS Teologiese Studies/Theological Studies, 2016
The parable of the Feast (Lk 14:16b–23) is perhaps the example par excellence in the New Testament that addresses spatial justice and reconciliation.
Ernest Van Eck, Wayne Renkin, Ezekiel Ntakirutimana   +2 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Absence, presence, remembrance: A theological essay on frailty, the university and the city

Verbum et Ecclesia, 2013
This essay is reflecting on frailty, the university and the city, in relation to each other. It seeks to transcend the binary concepts of presence and absence, proposing remembrance as the frail work of making absence present, of reweaving what is ...
Stephan F. de Beer
doaj  

The role of identity in the development of depressive, anxiety and psychosis symptoms in adolescents exposed to childhood adversity: a process-oriented approach

BMC Psychiatry
Background Childhood adversity is known to predispose to a wide array of psychopathology in adolescence and early adulthood. Identity development, being a crucial developmental task during adolescence, has been suggested to affect this association ...
Celine Samaey, Stijn Lambrechts, Aleksandra Lecei, Robin Achterhof, Noëmi Hagemann, Karlijn S. F. M. Hermans, Anu P. Hiekkaranta, Olivia J. Kirtley, Ulrich Reininghaus, Bart Boets, Inez Myin-Germeys, Ruud van Winkel   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source