Results 81 to 90 of about 384,374 (268)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

The ‘good city’ or ‘post-colonial catch-basins of violent empire’? A contextual theological appraisal of South Africa’s Integrated Urban Development Framework

open access: yesHTS Teologiese Studies/Theological Studies, 2016
The Integrated Urban Development Framework (IUDF) was constructed as a ‘new deal’ for South African cities and towns. It outlines a vision with four overarching goals and eight priorities or policy levers meant to overcome the apartheid legacy through ...
Stephan de Beer
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Social Cohesion in Australia: Comparing Church and Community

open access: yesReligions, 2019
In a context of increasing ethnic and religious diversity, Australia’s future prosperity may depend, in part, on the ability to maintain social cohesion. Drawing on the framework developed by the Scanlon Foundation Social Cohesion Research Program,
Miriam Pepper   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

In the light of the Spirit: the dual nature of the Third Person

open access: yesKoers : Bulletin for Christian Scholarship, 2000
Analogy with physical things and phenomena can be a useful tool in theology. In particular, the vestigia Trinitatis can be used to illustrate the doctrine of the Trinity, even if it is illegitimate to derive it from them.
David T. Williams
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

A kenotic response to secularity

open access: yesKoers : Bulletin for Christian Scholarship, 2008
The church must be concerned to make the correct response to its increasing impotence and marginalisation in Western society due to secularisation. Past reaction has been to accommodate to the changed worldview, even to identify with it.
D.T. Williams
doaj   +1 more source

Contextual Typing

open access: yesProceedings of the ACM on Programming Languages
Bidirectional typing is a simple, lightweight approach to type inference that propagates known type information during typing, and can scale up to many different type systems and features. It typically only requires a reasonable amount of annotations and eliminates the need for many obvious annotations ...
Xu Xue, Bruno C. d. S. Oliveira
openaire   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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