Results 121 to 130 of about 11,389,755 (299)
The Influence of E-Module Based on Contextual Approaches on Historical Thinking Skills
Yupa: Historical Studies JournalThis research is motivated by Kurikulum Merdeka in History lessons which contains achievements to be able to contextualize events that occurred in the past. The ability of teachers who have now developed by having the ability to create and use electronic-
Tiur Nurmayany Raharjo +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Distributionally Robust Contextual Optimization: A Generative Approach
We study distributionally robust contextual optimization, where a decision maker seeks a context-dependent policy that minimizes the worst-case expected loss over an ambiguity set of joint distributions of covariates and outcomes.
Gao, Rui
core
Edukasi Islami: Jurnal Pendidikan IslamBackground: This article is a literature review aimed at analyzing and explaining the contextual approach in enhancing the effectiveness of Islamic Religious Education (IRE) learning in Elementary Schools (ES).
Sitti Nadirah +4 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Relationship-based practice and contextual safeguarding: key messages for practice [PDF]
, 2020 This briefing explores the relationship between Contextual Safeguarding and Relationship-based Practice within social care and related youth and community work.
Millar, Hannah +4 more
core
COVID-19 in Ethiopia: A contextual approach to explaining its slow growth. [PDF]
J Glob Health, 2020 Wondimagegn D +11 more
europepmc +1 more source