Results 221 to 230 of about 1,142,494 (337)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Assessing stakeholder perceptions and contextual factors in implementing post-discharge malaria chemoprevention in children with severe anaemia in Malawi. [PDF]

BMC Health Serv Res
Ndambo MK, Hoyt J, Nyirongo E, Phiri KS, Hill J, Manda-Taylor L.   +5 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

How hospital doctors respond to contextual factors revealed by older patients with heart failure in hospital interactions: an interaction-based study. [PDF]

BMC Health Serv Res
Bjørnstad H, Frigaard C, Gulbrandsen P, Gerwing J, Schirmer H, Menichetti J.   +5 more
europepmc   +1 more source

Performance of indicators used in regular risk assessments for COVID-19 in association with contextual factors

Sujin Hong, Jiyoung Oh, Jia Lee, Yongmoon Kim, Bryan Kim, Min Jei Lee, Hyunjung Kim, Sangwoo Tak   +7 more
openalex   +1 more source

Additional file 1 of The WOMAN trial: clinical and contextual factors surrounding the deaths of 483 women following post-partum haemorrhage in developing countries

, 2020
Roberto Picetti, Lori K. Miller, Haleema Shakur‐Still, Tracey Pepple, Danielle Beaumont, Eni Balogun, Etienne Asonganyi, Rizwana Chaudhri, Mohamed A. El‐Sheikh, Bellington Vwalika, Sabaratnam Arulkumaran, Ian Roberts   +11 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Setting the stage for communication skills training in Rwandan cancer care: a qualitative study of local priorities and key contextual factors. [PDF]

BMC Palliat Care
Uwamahoro P, Girukubonye I, Bigirimana JB, Shyirambere C, Van Loon K, Sudore RL, Sanders JJ, Cubaka VK, DeBoer RJ.   +8 more
europepmc   +1 more source

Data from Cross-sectional Associations of Neighborhood Social and Environmental Contextual Factors with Telomere Length in Male and Female Health Professionals

Hari S. Iyer, Timothy R. Rebbeck, Elise G. Elliott, Michelle D. Holmes, Immaculata De Vivo, Francine Laden, Jaime E. Hart   +6 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source