Results 81 to 90 of about 8,037,414 (303)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Identification of the human factors contributing to maintenance failures in a petroleum operation

, 2010
Structured interviews (N=38) were conducted with maintainers in a petroleum company who were asked to discuss a maintenance failure with which they were familiar.
Ari Antonovsky, Straker, Leon M., Pollock, Clare, Antonovsky, Ari, Leon Straker, Pollock, Clare M. (R20416), Clare Pollock, Straker, Leon   +7 more
core   +1 more source

Summary statistics: Contextual factors.

, 2022
Summary statistics: Contextual factors.
Veronica Grembi (14013969), Emilia Barili (14013963), Paola Bertoli (14013966), Veronica Rattini (14013972)   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The effects of defensive style and final game outcome on the external training load of professional basketball players

Biology of Sport, 2020
This study aimed to analyse the influence of different contextual factors (i.e., defensive style and game outcome) on basketball players’ external load during games-based drills using ultrawideband (UWB) technology.
Daniel Castillo, Javier Raya-González, Filipe Clemente, Daniele Conte, Alejandro Rodríguez-Fernández   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Re-thinking the writing syllabus: How contextual factors inform curriculum revision

SOTL in the South
Recent studies demonstrate the effectiveness of needs analysis in relation to the language and communication goals of students. In this regard, different stakeholders contribute greatly to revision of curricula.
Jonna Marie Lim, Aireen Barrios, Gina Ugalingan, Philip Rentillo   +3 more
doaj   +1 more source

What Physiotherapists Specialized in Orthopedic Manual Therapy Know About Nocebo-Related Effects and Contextual Factors: Findings From a National Survey

Frontiers in Psychology, 2020
ObjectiveThe aim of this study was to investigate the knowledge of orthopedic manual therapists (OMTs) regarding context factors (CFs) capable of triggering nocebo effects during the treatment and how this knowledge is related to their socio-demographic ...
Giacomo Rossettini, Giacomo Rossettini, Tommaso Geri, Alvisa Palese, Chiara Marzaro, Mattia Mirandola, Luana Colloca, Luana Colloca, Mirta Fiorio, Andrea Turolla, Mattia Manoni, Marco Testa   +11 more
doaj   +1 more source