Results 211 to 220 of about 23,481 (290)

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Interpreting Blood Transfusion in Hip Fracture Surgery: Marker of Severity Rather Than Mediator of Harm? [Response to Letter]. [PDF]

J Blood Med
Al-Husinat L, Haddad F, Al Sharie S, Araydah M, Al Hseinat L, Kharashgah M, Alsharei A, Al Modanat Z, Alisi MS, Al-Ajlouni J, Dawod MS, De Rosa S, Battaglini D.   +12 more
europepmc   +1 more source

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source

Parameter efficient multi-model vision assistant for polymer solvation behaviour inference. [PDF]

NPJ Comput Mater
Liew ZJ, Elkhaiary Z, Lapkin AA.
europepmc   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Beyond incidence: clarifying the evidence-based predictors of failed spinal anesthesia. [PDF]

Patient Saf Surg
Mistry T, Nair AS.
europepmc   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce. [PDF]

Cardiovasc Diabetol
Wanner C, Cosentino F, Barnard-Kelly K, Battelino T, Blüher M, Boll HN, Brosius FC, Busetto L, Ceriello A, Gavin JR, Giorgino F, Green J, Ji L, Kellerer M, Koob S, Lalic N, Marx N, Nedungadi P, Parkin CG, Rodbard HW, Rydén L, Saboo B, Sheu WH, Standl E, Tacke F, Topsever P, Schnell O.   +26 more
europepmc   +1 more source

Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants

Advanced Science, EarlyView.
A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr, Reuben Rideaux, Amaya J. Fox, David R. Lightfoot, Jason Tangen, Jason B. Mattingley, Shane E. Ehrhardt   +6 more
wiley   +1 more source

Reducing Wait-Times for Orthopaedic Consultations for Patients with Knee Osteoarthritis Through Advanced Practice Physiotherapy. [PDF]

Health Serv Insights
Scarvell JM, Gilfillan D, Stewart TJ, McCrum CA, Fearon AM, Lynch JT, Ward T, Niyonsenga T.   +7 more
europepmc   +1 more source