Results 41 to 50 of about 17,664 (312)
‘Ought’-contextualism beyond the parochial [PDF]
, 2019 Despite increasing prominence, ‘ought’-contextualism is regarded with suspicion by most metaethicists. As I’ll argue, however, contextualism is a very weak claim, that every metaethicist can sign up to.
Worsnip, Alex
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Introduction—What is Epistemic Contextualism? [PDF]
, 2017 Introduces contextualism about knowledge ascriptions, and provides a brief summary of the contributions to the Routledge Handbook of Epistemic ...
Ichikawa, Jonathan Jenkins
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Do 'contextualist cases' support contextualism? [PDF]
, 2011 This paper addresses the argument from ‘contextualist cases’—such as for instance DeRose’s Bank cases—to attributor contextualism. It is argued that these cases do not make a decisive case against invariantism and that the debate between contextualists ...
Kelp, Christoph
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Contextualism and Knowledge Norms [PDF]
, 2017 I provide an opinionated overview of the literature on the relationship of contextualism to knowledge norms for action, assertion, and belief. I point out that contextualists about ‘knows’ are precluded from accepting the simplest versions of knowledge ...
Worsnip, Alex
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On Occasion: Invisible Minimalism and the Pragmatic Frame
Daimon, 2016 In the debate between literalism and contextualism in semantics, Kent Bach’s project is often taken to stand on the latter side of the divide. In this paper I argue that this is a misleading assumption and justify this by contrasting Bach’s assessment ...
Ana Falcato
doaj +1 more source
Does Contextualism Hinge on A Methodological Dispute? [PDF]
, 2017 In this entry, we provide an overview of some of the methodological debates surrounding contextualism and consider whether they are, in effect, based on an underlying methodological dispute.
Gao, Jie +2 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source