Results 41 to 50 of about 3,045 (256)
Архитектон, 2021 The article describes the process of identifying the regional specifics of historicism in the architecture of Ekaterinburg at the turn of the 21st century by studying retrospectively-oriented modern objects in the city with the help of a specially ...
Shipitsyna Olga A. +1 more
doaj +1 more source
Proceedings of the 7th International Conference on Performance Evaluation Methodologies and Tools, 2014 Quantitative analysis of computer systems is often based on Markovian models. Among the formalisms that are used in practice, Markovian process algebras have found many applications, also thanks to their compositional nature that allows one to specify systems as interacting individual automata that carry out actions.
J. Hillston +3 more
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Contextuality of Fallacies
Informal Logic, 2008 Van Eemeren and Houtlosser observe that Walton’s (and Walton and Krabbe’s) notion of ‘dialogue type’ involves a mixture of an empirical notion on a par with a speech event or activity type and a normative notion such as the model of a critical discussion.
van Eemeren, F.H., Houtlosser, P.
openaire +3 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Knowledge, chance, and contrast [PDF]
, 2012 The late 1980s and early 1990s saw the rise of contextualist theories of knowledge ascriptions (and denials). Contextualists about ‘knows’ maintain that utterances of the form ‘S knows p’ and ‘S doesn’t know p’ resemble utterances such as ‘Peter is ...
Dimmock, Paul
core
Skepticism about contextualism [PDF]
, 2005 Contextualism is the epistemological thesis that holds context to significantly affect the truth value of claims such as “S knows that p.” A shift in context can lead to a shift in the standards by which we evaluate propositional knowledge claims, and ...
Osborne III, William Galloway
core +2 more sources
The Many Uses of Predicates of Taste and the Challenge from Disagreement
Studies in Logic, Grammar and Rhetoric, 2016 In the debate between contextualism and relativism about predicates of taste, the challenge from disagreement (the objection that contextualism cannot account for disagreement in ordinary exchanges involving such predicates) has played a central role ...
Zeman Dan
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Semantic Error Problem for Epistemic Contextualism [PDF]
, 2017 Epistemic Contextualism is the view that “knows that” is semantically context-sensitive and that properly accommodating this fact into our philosophical theory promises to solve various puzzles concerning knowledge.
Greenough, Patrick Michael +1 more
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