Results 111 to 120 of about 1,938,271 (334)
Extranjeras encarceladas. Olvidos y desigualdades
Hachetetepé, 2011 El objetivo de este artículo es dar algunas pinceladas, a manera de síntesis, de las discriminaciones principales que están padeciendo las mujeres extranjeras encarceladas en nuestro país, desde una perspectiva crítica, no androcéntrica y transformadora ...
Elisabet Almeda Samaranch, Dino Di Nella
doaj
The Complexity of the Classification Problems of Finite-Dimensional Continua [PDF]
, 2019 Cheng Chang, Su Gao
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
La prensa local durante el primer peronismo en el municipio de La Matanza
Antigua Matanza, 2020 En las últimas décadas el peronismo incrementó su presencia como objeto de estudio historiográfico. Se dejaron de lado viejos enfoques y se analizaron nuevos temas desde perspectivas diversas.
Raúl Pomés
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Conmemoraciones sanmartinianas durante los gobiernos de la Revolución del 4 de junio de 1943
Antigua Matanza, 2017 Tanto los grupos que detentaron el poder, como los que luchan por alcanzarlo, utilizaron como herramienta al pasado y sobre todo a algunos referentes de ese pasado que puestos en el presente adquieren especiales significados.
Raúl ´Pomés
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source