Results 71 to 80 of about 1,928,367 (285)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Praxis EducativaResumen El artículo presenta resultados de una indagación referida a la implementación de la política educativa de Jornada Completa[i] desarrollada en la provincia de Río Negro desde 2013.
Noemi Cristina Souza, Gricelda Ibaceta
doaj +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Transactions of the American Mathematical Society, 1975 We define and investigate a class of continua called weakly smooth. Smooth dendroids, weakly smooth dendroids, generalized trees, and smooth continua are all examples of weakly smooth continua. We generalize characterizations of the above mentioned examples to weakly smooth continua. In particular, we characterize them as compact Hausdorff spaces which
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FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Enseñanza del concepto de densidad a través de un modelo analógico
Revista de Enseñanza de la Física, 2010 A pesar de que algunos conceptos básicos e iniciales del currículo de ciencias, como masa, volumen y densidad, se enseñan en varios niveles educativos persisten dificultades en estudiantes que cursan el nivel terciario y el ...
Andrés Raviolo +2 more
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ARIADNEplus: l’avventura continua
DigItalia, 2020 L’articolo descrive il progetto europeo ARIADNEplus, continuazione del precedente progetto ARIADNE. Questo nuovo progetto ha, come il precedente, l’obiettivo di superare la frammentazione degli archivi digitali di dati archeologici europei disponibili online attraverso la creazione di un catalogo. Rispetto al precedente progetto, ARIADNEplus ne estende
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source