Results 101 to 110 of about 82,184 (301)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Relating career stage to attitudes towards HR practices and commitment: evidence of interaction effects? [PDF]

open access: yes, 2003
A dominant theme within the HRM literature concerns the identification of 'best practices' that will enhance both organisational performance and employee commitment.
Conway, Edel
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

GENERATIONAL DIVERSITY, PERSONAL ATTRIBUTES AND ORGANIZATIONAL COMMITMENT AMONG EMPLOYEES OF CORPORATE CONSULTANCIES

open access: yesJurnal Manajemen dan Wirausaha, 2020
The main objective of this paper was to examine relationships of generational diversity, personal attributes (i.e., work values; attitudes and behavior; and interpersonal skills) on organizational commitment among employees of corporate consultancies ...
Purani Verasamy   +2 more
doaj   +1 more source

El compromiso en la empresa familar bajo una óptica de liderazgo transformacional y aprendizaje organizacional [PDF]

open access: yes, 2007
The main contribution of this paper is just to demonstrate that the existence of higher level of organizational commitment in family firms is due to transformational leadership and can be explained adopting an approach of cognitive organizational ...
Vallejo Martos, M. C.
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

The influence of occupational rank on organizational commitment of faculty members

open access: yesManagement : Journal of Contemporary Management Issues, 2015
This study investigates the impact of rank on organizational commitment and explores the individual relationships between affective, normative and continuance commitment.
Vinita Sinha, Pooja Sharma
doaj  

Forms of commitment: continuity and rupture

open access: yes, 2021
The authority of the committed writer has declined in France since the late 1970s, due to a combination of factors. However, a phenomenon of repoliticization can currently be observed, in two forms: on the one hand, with festivals and writers’ residencies, new spaces of intervention in the city are opening up to writers, inaugurating a form that can be
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

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