Results 91 to 100 of about 291,339 (267)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Golden Ratio and a Ramanujan-Type Integral

Axioms, 2013
In this paper, we give a pedagogical introduction to several beautiful formulas discovered by Ramanujan. Using these results, we evaluate a Ramanujan-type integral formula. The result can be expressed in terms of the Golden Ratio.
Hei-Chi Chan
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Elliptic Biorthogonal Polynomials Connected with Hermite's Continued Fraction

Symmetry, Integrability and Geometry: Methods and Applications, 2007
We study a family of the Laurent biorthogonal polynomials arising from the Hermite continued fraction for a ratio of two complete elliptic integrals. Recurrence coefficients, explicit expression and the weight function for these polynomials are obtained.
Luc Vinet, Alexei Zhedanov
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Some formulas related to Euler's product expansion for cosine function [PDF]

Notes on Number Theory and Discrete Mathematics
In this paper, we derive by using elementary methods some continued fractions, certain identities involving derivatives of tan x, several expressions for log cosh x and an identity for π², from a series expansion of tan x, which gives the product ...
Taekyun Kim, Dae San Kim
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

On the analytic extension of three ratios of Horn's confluent hypergeometric function $\mathrm{H}_7$

Researches in Mathematics
In this paper, we consider the extension of the analytic functions of two variables by special families of functions — continued fractions. In particular, we establish new symmetric domains of the analytical continuation of three ratios of Horn's ...
V. Hladun, R. Rusyn, M. Dmytryshyn
doaj   +1 more source

Continued Fractions and Factoring

, 2019
Legendre found that the continued fraction expansion of $\sqrt N$ having odd period leads directly to an explicit representation of $N$ as the sum of two squares. Similarly, it is shown here that the continued fraction expansion of $\sqrt N$ having even period directly produces a factor of a composite $N$.
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source