Results 91 to 100 of about 1,655,397 (309)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Evaluation of fostering network Scottish care mentoring projects [PDF]
, 2005 Looked after children and young people are some of the most vulnerable in our society. For Scotland’s Children highlighted the ‘continuing failure of many local authorities as ‘corporate parents’ to provide these young people with the care and education ...
Cadman, M., Hunter, L., Kendrick, A.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Rehabilitation SciencesPurposeTo develop a continuing care intervention program based on an information platform and evaluate its effectiveness in discharged patients with first-ever stroke.Materials and methodsA total of 90 eligible patients were randomly assigned to a ...
Lai Wenping, Du Xiaojun, Wang Liyan
doaj +1 more source
Relapse prevention for addictive behaviors
Substance Abuse Treatment, Prevention, and Policy, 2011 The Relapse Prevention (RP) model has been a mainstay of addictions theory and treatment since its introduction three decades ago. This paper provides an overview and update of RP for addictive behaviors with a focus on developments over the last decade (
George William H +3 more
doaj +1 more source
Like Disney For Adults: Life In Freedom Village [PDF]
, 2016 With an increasingly aging population, American society needs to more effectively address living options for the aging population in the present and future. Older adults have unique needs due to their age, physical and mental condition, varying needs for
Schuster, Janice G.
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Whither human survival and longevity or the shape of things to come [PDF]
, 2009 With the continuing increases in life expectancy, populations are ageing rapidly. Governments are concerned for the future of pensions and health care for which population forecasts are an important component for planning purposes. In this paper we focus
Mayhew, L., Smith, D.
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Proceedings of Singapore Healthcare, 2019 Introduction: This study aims to determine the effectiveness, cost savings and feasibility of implementing a systematic process of deprescribing medications for symptomatic management, namely, acid suppressants, laxatives, analgesics and antiemetics for ...
Charissa Ann Jia Ming Ee +3 more
doaj +1 more source