Results 111 to 120 of about 1,655,397 (309)
Digital approaches to continuing care. [PDF]
Curr Opin Psychiatry, 2022 McKay JR.
europepmc +1 more source
Immigrant Labor, Child-Care Services, and the Work-Fertility Trade-Off in the United States [PDF]
The negative correlation between female employment and fertility in industrialized nations has weakened since the 1960s, particularly in the United States. We suggest that the continuing influx of low-skilled immigrants has led to a substantial reduction
Furtado, Delia, Hock, Heinrich
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A training needs analysis of health care providers within Malta’s Primary Health Department : a boon or a bane? [PDF]
, 2012 In 2009, the Practice Development Unit and the Specialist Training Programme in Family Medicine within Malta’s Primary Health Department carried out a training needs analysis of health care providers working in government primary health centres and ...
Bombagi, Mariella +2 more
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
NHS Continuing Healthcare funding: anomalous, irregular, and often baffling [PDF]
, 2017 The boundary between health and social care continues to be a major issue, and is especially stark around long-term care and NHS continuing healthcare.
Henwood, Melanie
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Escaping the frameworks: Arguments for CPD as a practice-led break-out from normative occupational standards in health and social care [PDF]
, 2008 The newly introduced CPD structures of post-registration training and learning requirements for registered social workers are already under review to examine whether they are ‘fit for purpose’.
Cooper, Barry
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source