Results 21 to 30 of about 10,324 (222)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Interdisciplinary approach to the demography of Jamaica [PDF]

, 2012
<p>Background: The trans-Atlantic slave trade dramatically changed the demographic makeup of the New World, with varying regions of the African coast exploited differently over roughly a 400 year period.
Salas Ellacuriaga, Antonio, Newman, Simon P., Pitsiladis, Yannis; id_orcid, Pitsiladis, Yannis P., Morrison, Errol Y st A., Antonio Salas, Newman Simon P, Simon P Newman, Salas Antonio, Errol Y st A Morrison, Salas, A., Morrison, E.Y., Deason Michael L, Pitsiladis Yannis P, Michael L Deason, Salas, Antonio, Yannis P Pitsiladis, Pitsiladis, Y.P., Macaulay, Vicent A., DEASON, M., Macaulay, V.A., Newman, S.P., Macaulay Vincent A, st A Morrison Errol Y, Vincent A Macaulay, Deason, Michael L.   +25 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Affiliation: Memories as religion: What can the broken continuity of tradition bring about? − Part two

, 2020
In postmodern societies the symbolic vacuum, a result of the loss of a unified religious tradition, calls for substitutes in the form of fragmentary and isolated memories. By drawing from the reservoir of those memories in an arbitrary and subjective way,
Jakub Urbaniak
core  

Integration of tuberculosis (TB) and HIV services in Ghana [PDF]

, 2011
Integration of health services involves managing services to enhance quality for patient needs that cut across multiple services, providers and settings. The rapid growth of human immunodeficiency virus (HIV) has increased tuberculosis (TB) cases, and TB/
Ansa, Gloria Akosua
core  

A Framework for Omnichannel Differentiation Strategy. Integrating the Information Delivery and Product Fulfillment Requirements.

, 2018
Technology and innovation have the capability to change the many aspects of business for good and bad. With technology capabilities, customers are demanding for better products and service delivery anytime, anywhere.
Kassim, Erne Suzila, Hussin, Husnayati, Husnayati Hussin, Erne Suzila Kassim   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

4 - Etude socioculturelle de l\u27entreprise sénégalaise

, 1995
The authors selected nineteen (19) large-scale enterprises, including fourteen (14) public and five (5) private enterprises. Within these some 754 workers were asked questions relating to their age gender, family status, level of education, ethnic and ...
Adama Gaye, Tidjani, Bassirou
core   +1 more source