Results 61 to 70 of about 10,324 (222)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Research report: Studying the religious socialization of Sikh and 'mixed-faith' youth in Britain: contexts and issues [PDF]

open access: yes
Against a backdrop of phases of Sikh settlement in the UK, this article provides an overview of scholarship on UK Sikh communities. Attention turns to four ethnographic studies conducted by the author, two of which focused on unambiguously Sikh ...
Nesbitt, Eleanor
core   +1 more source

A study of the late prehistoric burial records of Xinjiang, northwest China (c. 3000−200BCE) [PDF]

open access: yes, 2021
Xinjiang is well known as a key part of the ancient Silk Road. Since the start of research on Xinjiang’s prehistory, the archaeological records have been dominated by burials.
Qi, Meng
core  

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

Molecular insight into the population structure of common and spotted dolphins inhabiting the pelagic waters of the Northeast Atlantic

open access: yes, 2010
Several cetacean species exhibit fine-scale population structure despite their high dispersal capacities and the apparent continuity of the marine environment.
Joana R. Almeida   +21 more
core   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi   +17 more
wiley   +1 more source

Research on Preservice Teachers' SMK about Differentiation Concept

open access: yes, 2013
본 연구의 목적은 예비 수학교사들의 미분 개념에 대한 SMK의 특징과 그 하위 영역이 어떻게 형성되고 있는지에 대해 조사하고자 하는데 있다. 예비교사가 실제 수업 현장에서 다루게 될 내용을 고려하기 때문에 SMK는 중등학교 수준의 미분 개념이 된다. 교사는 가르치는 능력 뿐 아니라 수학 교과 내용 지식에 대한 정확한 이해가 바탕이 되어야 한다. 따라서 선행 연구를 바탕으로 예비교사의 SMK를 이해하기 위하여 다음과 같은 연구 문제를 설정하였다. 1.
강민지
core  

We often see lists of 'top' schools. But what makes a good school for your child?

open access: yes
In public discourse, rankings and “top school lists” often dominate perceptions of educational quality. However, for parents seeking the best environment for their child, a school’s ranking alone is insufficient and sometimes misleading.
Brownlie, Nicole, Desmarchelier, Renee
core   +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

open access: yesArthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk   +16 more
wiley   +1 more source

The Role of Materials Research in Ceramics and Archaeology

open access: yes, 2001
▪ Abstract  Materials research has been applied successfully to the study of archaeological ceramics for the last fifty years. To learn about our history and the human condition is not just to analyze and preserve the objects but also to investigate and
Pamela Vandiver
core   +1 more source

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