Results 41 to 50 of about 472,515 (287)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

Arthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk, Jing Li, Cathy Nasrallah, Cherish Wilson, Alicia Hamblin, Christine Hariz, Cammie Young, Stephen Shiboski, Emma Kersey, Mary Nakamura, Judith F. Ashouri, Mehrdad Matloubian, Andrew J. Gross, Jennifer Barton, Beth Berrean, Jonathan Prugh, Jinoos Yazdany   +16 more
wiley   +1 more source

Solar sailing: mission applications and engineering challenges [PDF]

, 2003
Solar sailing is emerging as a promising form of advanced spacecraft propulsion, which can enable exciting new space-science mission concepts. By exploiting the momentum transported by solar photons, solar sails can perform high-energy orbit transfer ...
McInnes, C.R.
core   +2 more sources

A Delivery Robot Cloud Platform Based on Microservice

Journal of Robotics, 2021
Delivery robots face the problem of storage and computational stress when performing immediate tasks, exceeding the limits of on-board computing power.
Zuozhong Yin, Jihong Liu, Bin Chen, Chuanjun Chen   +3 more
doaj   +1 more source

A Review of Interference Reduction in Wireless Networks Using Graph Coloring Methods

, 2011
The interference imposes a significant negative impact on the performance of wireless networks. With the continuous deployment of larger and more sophisticated wireless networks, reducing interference in such networks is quickly being focused upon as a ...
Chickadel, Andrew, Hassan, Maaly Awad
core   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Sequential Decision Algorithms for Measurement-Based Impromptu Deployment of a Wireless Relay Network along a Line

, 2015
We are motivated by the need, in some applications, for impromptu or as-you-go deployment of wireless sensor networks. A person walks along a line, starting from a sink node (e.g., a base-station), and proceeds towards a source node (e.g., a sensor ...
Chattopadhyay, Arpan, Coupechoux, Marceau, Kumar, Anurag   +2 more
core   +3 more sources

The Impact of Conventional Force Reductions on Strategic Deterrence: A Game-Theoretic Analysis [PDF]

, 2001
Many game-theoretic analyses of deterrence confirm the commonsense view that what determines whether a defender can effectively deter a challenger from an unwanted action is (1) the challenger’s perception of the level of punishment that the defender ...
Kilgour, D. Marc, Zagare, Frank C.
core   +2 more sources

A Robust Adaptive One‐Sample‐Ahead Preview Super‐Twisting Sliding Mode Controller

International Journal of Adaptive Control and Signal Processing, EarlyView.
Block Diagram of the Robust Adaptive One‐Sample‐Ahead Preview Super‐Twisting Sliding Mode Controller. ABSTRACT This article introduces a discrete‐time robust adaptive one‐sample‐ahead preview super‐twisting sliding mode controller. A stability analysis of the controller by Lyapunov criteria is developed to demonstrate its robustness in handling both ...
Guilherme Vieira Hollweg, Paulo Jefferson Dias de Oliveira Evald, Shivam Chaturvedi, Hilton Abilio Gründling, Rodrigo Varella Tambara, Wencong Su   +5 more
wiley   +1 more source