Control strategy and methods for continuous direct compression processes [PDF]
Asian Journal of Pharmaceutical Sciences, 2021 We presented a control strategy for tablet manufacturing processes based on continuous direct compression. The work was conducted by the experts of pharmaceutical companies, machine suppliers, academia, and regulatory authority in Japan.
Yasuhiro Suzuki +16 more
doaj +5 more sources
Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance [PDF]
Pharmaceutics, 2023 The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively ...
Owen Jones-Salkey +3 more
doaj +6 more sources
Batch vs. continuous direct compression – a comparison of material processability and final tablet quality [PDF]
International Journal of Pharmaceutics: X, 2023 In this study, an in-depth comparison was made between batch and continuous direct compression using similar compression set-ups. The overall material processability and final tablet quality were compared and evaluated.
B. Bekaert +7 more
doaj +8 more sources
Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation [PDF]
International Journal of Pharmaceutics: X, 2022 In this study, an empirical predictive model was developed based on the quantitative relationships between blend properties, critical quality attributes (CQA) and critical process parameters (CPP) related to blending and tableting.
B. Bekaert +7 more
doaj +7 more sources
The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process [PDF]
Pharmaceutics, 2020 Segregation is a common problem in batch-based direct compression (BDC) processes, especially with low-dose tablet products, as is the preparation of a homogenous mixture.
Tuomas Ervasti +6 more
doaj +7 more sources
Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in a Continuous Direct Compression Line [PDF]
Pharmaceutics, 2022 The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line.
Marius J. Kreiser +2 more
doaj +4 more sources
Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting Process [PDF]
Pharmaceutics, 2023 Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control.
Gerald A. Hebbink +7 more
doaj +5 more sources
Continuous direct compression as manufacturing platform for sustained release tablets [PDF]
International Journal of Pharmaceutics, 2017 This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
B. Van Snick +7 more
core +7 more sources
International Journal of Pharmaceutics, 2022 Continuous tablet manufacturing is a competitive option to replace the traditional batch manufacturing approach. The aim of this study was to evaluate technology transfer from batch-based direct compression of a commercial tablet formulation to continuous direct compression without changes to the composition of the formulation. Some powder studies were
Jenna Lyytikäinen +6 more
openalex +3 more sources
Robustness of a continuous direct compression line against disturbances in feeding
International Journal of Pharmaceutics, 2019 The aim of the current study was to characterize the robustness of an integrated continuous direct compression (CDC) line against disturbances from feeding, i.e. impulses of API and short step disturbances. These disturbances mimicked typical variations that can be encountered during long-term manufacture. The study included a primary formulation, with
Anssi-Pekka Karttunen +13 more
openalex +5 more sources