Results 11 to 20 of about 360,304 (270)

Robustness of a continuous direct compression line against disturbances in feeding

International Journal of Pharmaceutics, 2020
The aim of the current study was to characterize the robustness of an integrated continuous direct compression (CDC) line against disturbances from feeding, i.e. impulses of API and short step disturbances. These disturbances mimicked typical variations that can be encountered during long-term manufacture. The study included a primary formulation, with
Karttunen, A-P, Poms, J, Sacher, S, Sparén, A, Ruiz Samblás, C, Fransson, M, Martin De Juan, L, Remmelgas, J, Wikström, H, Hsiao, W K, Folestad, S, Korhonen, O, Abrahmsén-Alami, S, Tajarobi, P   +13 more
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Provoking an end-to-end continuous direct compression line with raw materials prone to segregation

European Journal of Pharmaceutical Sciences, 2017
Continuous manufacturing of solid oral dosage forms is promising for increasing the efficiency and quality of pharmaceutical production and products. In this study a whole train continuous direct compression (CDC) line has been provoked using challenging formulations typically prone to segregation in batch powder processing.
Satu Lakio, Tuomas Ervasti, Pirjo Tajarobi, Håkan Wikström, Magnus Fransson, Anssi-Pekka Karttunen, Jarkko Ketolainen, Staffan Folestad, Susanna Abrahmsén-Alami, Ossi Korhonen   +9 more
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Comparison between integrated continuous direct compression line and batch processing – The effect of raw material properties

European Journal of Pharmaceutical Sciences, 2019
There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression (CDC) line, in relation to batch processing, to achieve consistent tablet quality over long processing periods for formulations
Anssi-Pekka Karttunen, Håkan Wikström, Pirjo Tajarobi, Magnus Fransson, Anders Sparén, Mariagrazia Marucci, Jarkko Ketolainen, Staffan Folestad, Ossi Korhonen, Susanna Abrahmsén-Alami   +9 more
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Development and Use of a Residence Time Distribution (RTD) Model Control Strategy for a Continuous Manufacturing Drug Product Pharmaceutical Process

Pharmaceutics, 2022
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal of non ...
Samantha Hurley, Anthony Tantuccio, Manuel Sebastian Escotet-Espinoza, Matthew Flamm, Matthew Metzger   +4 more
doaj   +1 more source

Performance Analysis of a Biodiesel-Fired Engine for Cogeneration [PDF]

E3S Web of Conferences, 2021
The continuous demand to reduce both the pollutant emissions and the greenhouse gas (GHG) is increasing the use of alternative fuels as biodiesel in direct-injection compression ignition engines under combined heat and power (CHP) configuration. Although
Falbo Luigi, Ramundo Ernesto
doaj   +1 more source

Compression Analysis of Hollow Cylinder Basalt Continuous Filament Epoxy Composite Filled with Shape Memory Wire [PDF]

Mechanics of Advanced Composite Structures, 2017
This paper presents an experimental investigation into the compression behavior of shape memory alloy hybrid composites (SMAHC) subjected to quasi-static loading taking into account of rotation effects of shape memory wire in basalt continuous filament ...
Mohammad Reza Khalili, Morteza Rajabpour, Mohammad Reza Jafarinezhad, Roham Maher   +3 more
doaj   +1 more source

Evolution of Preset Void and Damage Characteristics in Aluminum during Shock Compression and Release

Nanomaterials, 2022
It is well known that initial defects play an essential role in the dynamic failure of materials. In practice, dynamic tension is often realized by release of compression waves.
Ya-Ting Wan, Jian-Li Shao, Guang-Ze Yu, Er-Fu Guo, Hua Shu, Xiu-Guang Huang   +5 more
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Direct Comparison of the Structural Compression Characteristics of Natural and Synthetic Fiber-Epoxy Composites: Flax, Jute, Hemp, Glass and Carbon Fibers

Fibers, 2020
Recent decades have seen substantial interest in the use of natural fibers in continuous fiber reinforced composites, such as flax, jute and hemp. Considering potential applications, it is of particular interest how natural fiber composites compare to ...
Mike R. Bambach
doaj   +1 more source

Parameter optimization in a continuous direct compression process of commercially batch-produced bisoprolol tablets

International Journal of Pharmaceutics, 2022
Continuous tablet manufacturing is a competitive option to replace the traditional batch manufacturing approach. The aim of this study was to evaluate technology transfer from batch-based direct compression of a commercial tablet formulation to continuous direct compression without changes to the composition of the formulation. Some powder studies were
Jenna Lyytikäinen, Pawel Stasiak, Tomáš Kubelka, Tino Olenius, Ossi Korhonen, Jarkko Ketolainen, Tuomas Ervasti   +6 more
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The Influence of Loading Rate on Direct and Indirect Tensile Strengths: Laboratory and Numerical Methods

Shock and Vibration, 2021
To investigate different responses of direct and indirect tensile strengths to loading rate, direct and indirect tension tests were performed on sandstone, rust stone, and granite specimens.
Jie Liu, Gangyuan Jiang, Taoying Liu, Qiao Liang   +3 more
doaj   +1 more source