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Control strategy and methods for continuous direct compression processes [PDF]

Asian Journal of Pharmaceutical Sciences, 2021
We presented a control strategy for tablet manufacturing processes based on continuous direct compression. The work was conducted by the experts of pharmaceutical companies, machine suppliers, academia, and regulatory authority in Japan.
Yasuhiro Suzuki, Hirokazu Sugiyama, Manabu Kano, Ryutaro Shimono, Gosuke Shimada, Ryoichi Furukawa, Eichi Mano, Keiichi Motoyama, Tatsuo Koide, Yasuhiro Matsui, Kazuki Kurasaki, Issei Takayama, Shunin Hikage, Noriko Katori, Masahiko Kikuchi, Hiroshi Sakai, Yoshihiro Matsuda   +16 more
doaj   +6 more sources

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance [PDF]

Pharmaceutics, 2023
The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively ...
Owen Jones-Salkey, Zoe Chu, Andrew Ingram, Christopher R. K. Windows-Yule   +3 more
doaj   +6 more sources

The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process [PDF]

Pharmaceutics, 2020
Segregation is a common problem in batch-based direct compression (BDC) processes, especially with low-dose tablet products, as is the preparation of a homogenous mixture.
Tuomas Ervasti, Hannes Niinikoski, Eero Mäki-Lohiluoma, Heidi Leppinen, Jarkko Ketolainen, Ossi Korhonen, Satu Lakio   +6 more
doaj   +7 more sources

Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation [PDF]

International Journal of Pharmaceutics: X, 2022
In this study, an empirical predictive model was developed based on the quantitative relationships between blend properties, critical quality attributes (CQA) and critical process parameters (CPP) related to blending and tableting.
B. Bekaert, B. Van Snick, K. Pandelaere, J. Dhondt, G. Di Pretoro, T. De Beer, C. Vervaet, V. Vanhoorne   +7 more
doaj   +5 more sources

Batch vs. continuous direct compression – a comparison of material processability and final tablet quality [PDF]

International Journal of Pharmaceutics: X
In this study, an in-depth comparison was made between batch and continuous direct compression using similar compression set-ups. The overall material processability and final tablet quality were compared and evaluated.
B. Bekaert, P.H.M. Janssen, S. Fathollahi, D. Vanderroost, T. Roelofs, B.H.J. Dickhoff, C. Vervaet, V. Vanhoorne   +7 more
doaj   +6 more sources

Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in a Continuous Direct Compression Line [PDF]

Pharmaceutics, 2022
The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line.
Marius J. Kreiser, Christoph Wabel, Karl G. Wagner   +2 more
doaj   +2 more sources

Continuous direct compression as manufacturing platform for sustained release tablets [PDF]

International Journal of Pharmaceutics, 2017
This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
Cunningham, C., De Beer, Thomas, Holman, J., Kumar, Ashish, Remon, Jean Paul, Van Snick, Bernd, Vercruysse, Jurgen, Vervaet, Chris   +7 more
core   +4 more sources

Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting Process

Pharmaceutics, 2023
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control.
Gerald A. Hebbink, Pauline H. M. Janssen, Jurjen H. Kok, Lorenzo Menarini, Federica Giatti, Caterina Funaro, Salvatore Fabrizio Consoli, Bastiaan H. J. Dickhoff   +7 more
doaj   +4 more sources

Quantifying Hidden Order out of Equilibrium

Physical Review X, 2019
While the equilibrium properties, states, and phase transitions of interacting systems are well described by statistical mechanics, the lack of suitable state parameters has hindered the understanding of nonequilibrium phenomena in diverse settings, from
Stefano Martiniani, Paul M. Chaikin, Dov Levine   +2 more
doaj   +2 more sources

Life cycle assessment of pharmaceutical tablet manufacturing: A comparative analysis and systems model integration framework [PDF]

International Journal of Pharmaceutics: X
Pharmaceutical drug products in the form of tablets are produced via a series of manufacturing steps, transforming powder blends to compacted granules with carefully selected properties such as tensile strength and dissolution time.
Flora Bouchier, Astrid Boje, Gavin Reynolds   +2 more
doaj   +2 more sources