Results 11 to 20 of about 357,777 (201)

Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders [PDF]

AAPS PharmSciTech, 2023
Abstract Tribo-charging is often a root cause of mass flow deviations and powder adhesion during continuous feeding. Thus, it may critically impact product quality. In this study, we characterized the volumetric (split- and pre-blend) feeding behavior and process-induced charge of two direct compression grades of polyols, galenIQ™ 721 (G721) for ...
Michela Beretta, Julia Kruisz, Theresa Hörmann, Viktoria Magosi, Meishan Guo, Majid Naderi, Sarah Heupl, Johann Kastner, Martin Spoerk, Amrit Paudel   +9 more
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Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression [PDF]

International Journal of Pharmaceutics
Continuous manufacturing offers advantages over traditional batch methods, including agility, efficiency, and sustainability. However, transitioning to continuous manufacturing in process development is challenging due to the need for early adoption of industrial-scale equipment.
Kensaku Matsunami, Alexander Ryckaert, Hanne Verrecas, Ana Filipa Tavares da Silva, Andrew E. Anderson, Håkan Wikström, Melanie Dumarey, James Mann, Thomas De Beer, Valérie Vanhoorne, Ashish Kumar   +10 more
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Data-driven Modeling of a Continuous Direct Compression Tableting Process using SINDy [PDF]

Systems and Control Transactions
Understanding the complex dynamics of continuous processes in pharmaceutical manufacturing is essential to ensure product quality across the production line. This paper presents a data-driven modeling approach using Sparse Identification of Nonlinear Dynamics with Control (SINDYc) to capture the dynamics of a continuous direct compression (CDC ...
Pau Lapiedra Carrasquer, Satyajeet Bhonsale, Carlos Andr� Mu�oz L�pez, Kris Dockx, Jan Van Impe   +4 more
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Life cycle assessment of pharmaceutical tablet manufacturing: A comparative analysis and systems model integration framework [PDF]

International Journal of Pharmaceutics: X
Pharmaceutical drug products in the form of tablets are produced via a series of manufacturing steps, transforming powder blends to compacted granules with carefully selected properties such as tensile strength and dissolution time.
Flora Bouchier, Astrid Boje, Gavin Reynolds   +2 more
doaj   +2 more sources

Continuous direct compression of a commercially batch-manufactured tablet formulation with two different processing lines

European Journal of Pharmaceutics and Biopharmaceutics
The transfer from batch-based to continuous tablet manufacturing increases the quality and efficiency of processes. Nonetheless, as in the development of a batch process, the continuous process design requires optimization studies to ensure a robust process.
Jenna Lyytikäinen, Pawel Stasiak, Tomáš Kubelka, Ivan Bogaerts, Adam Waněk, Bart Stynen, James Holman, Jarkko Ketolainen, Tuomas Ervasti, Ossi Korhonen   +9 more
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Process intensification using a semi-continuous mini-blender to support continuous direct compression processing

Powder Technology, 2023
Maarten Jaspers, Timo P. Roelofs, Alexandra Lohrmann, Florian Tegel, Muhammad Khalid Maqsood, Yunfei Song, Bernhard Meir, Richard Elkes, Bastiaan H.J. Dickhoff   +8 more
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Using AI/ML to predict blending performance and process sensitivity for Continuous Direct Compression (CDC)

International Journal of Pharmaceutics
Utilising three artificial intelligence (AI)/machine learning (ML) tools, this study explores the prediction of fill level in inclined linear blenders at steady state by mapping a wide range of bulk powder characteristics to processing parameters. Predicting fill levels enables the calculation of blade passes (strain), known from existing literature to
Owen Jones‐Salkey, Kit Windows‐Yule, A. Ingram, L. Stahler, Andrei L. Nicuşan, S. M. Clifford, Luis Martín de Juan, Gavin Reynolds   +7 more
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Comparison between integrated continuous direct compression line and batch processing – The effect of raw material properties

European Journal of Pharmaceutical Sciences, 2019
There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression (CDC) line, in relation to batch processing, to achieve consistent tablet quality over long processing periods for formulations
Anssi-Pekka Karttunen, Håkan Wikström, Pirjo Tajarobi, Magnus Fransson, Anders Sparén, Mariagrazia Marucci, Jarkko Ketolainen, Staffan Folestad, Ossi Korhonen, Susanna Abrahmsén‐Alami   +9 more
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Multivariate analysis of a direct compression pharmaceutical tablets continuous manufacturing process

, 2018
Historicamente, a produção em descontínuo de formas de dosagem sólidas teve grande sucesso e dominou a indústria farmacêutica. Durante muito tempo a indústria entendeu não haver motivação para inovar no sentido do desenvolvimento de novas tecnologias de fabrico, dada a rentabilidade desta forma de produção.
Sílvia Maria Mesquita Ribeiro Miranda
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Provoking an end-to-end continuous direct compression line with raw materials prone to segregation

European Journal of Pharmaceutical Sciences, 2017
Continuous manufacturing of solid oral dosage forms is promising for increasing the efficiency and quality of pharmaceutical production and products. In this study a whole train continuous direct compression (CDC) line has been provoked using challenging formulations typically prone to segregation in batch powder processing.
Satu Lakio, Tuomas Ervasti, Pirjo Tajarobi, Håkan Wikström, Magnus Fransson, Anssi-Pekka Karttunen, Jarkko Ketolainen, Staffan Folestad, Susanna Abrahmsén‐Alami, Ossi Korhonen   +9 more
openalex   +5 more sources