Results 221 to 230 of about 28,705 (244)

From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses

Industrial & Engineering Chemistry Research, 2019
In response to the current trend in the pharmaceutical industry, a new concept for the freeze-drying of pharmaceuticals in unit-doses is presented: the continuous freeze-drying/lyophilization of su...
Luigi C. Capozzi, Bernhardt L. Trout, Roberto Pisano   +2 more
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Investigation of Continuous and Intermittent Heating on Far-Infrared Assisted Freeze-Drying

Transactions of the ASABE, 2009
Freeze-drying of sweet potato was studied using continuous and intermittent far-infrared (FIR) assisted heating in this study. Intermittency levels of a = 0, 0.25, 0.5, 0.75, and 1 were applied with a cycle time of 30 min, and it was found that the optimum intermittency level was a = 0.5.
null V. A.-E. King, null Y.-P. Lin
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Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

Analytical Chemistry, 2018
Near-infrared chemical imaging (NIR-CI) is an emerging tool for process monitoring because it combines the chemical selectivity of vibrational spectroscopy with spatial information. Whereas traditional near-infrared spectroscopy is an attractive technique for water content determination and solid-state investigation of lyophilized products, chemical ...
Davinia Brouckaert, Laurens De Meyer, Brecht Vanbillemont, Pieter-Jan Van Bockstal, Joris Lammens, Séverine Mortier, Jos Corver, Chris Vervaet, Ingmar Nopens, Thomas De Beer   +9 more
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Evaluation of immersion‐contact type heat transfer for continuous pharmaceutical spin freeze‐drying process

Journal of Food Process Engineering, 2019
AbstractSpin freeze‐drying process is a recently proposed method to achieve continuous processing of unit doses in freeze‐drying application. An experimental study is carried out to investigate the heat transfer and drying characteristics of a spin‐frozen liquid product.
Ganeshmurthy Srinivasan, Balakrishnan Raja   +1 more
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Continuous measurement of drying rate of crystalline and amorphous systems during freeze‐drying using an in situ microbalance technique

Journal of Pharmaceutical Sciences, 2001
The use of a novel microbalance (Christ) technique to monitor continuously the weight loss of a vial standing on a shelf of a freeze-dryer has been investigated. The drying rates of the following aqueous solutions were measured during the primary drying phase of a complete freeze-drying cycle: sucrose (75 mg/mL, 2.5-mL fill volume), sucrose and ...
C, Roth, G, Winter, G, Lee
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The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

International Journal of Pharmaceutics, 2018
Recently, a continuous freeze-drying process for the production of unit doses was presented and evaluated. In this concept, the freezing step is modified compared to traditional batch freeze-drying, as glass vials filled with a liquid formulation, are rotated around their longitudinal axis while cooled and frozen with a cold, sterile and inert gas (i.e.
Joris, Lammens, Séverine Thérèse F C, Mortier, Laurens, De Meyer, Brecht, Vanbillemont, Pieter-Jan, Van Bockstal, Simon, Van Herck, Jos, Corver, Ingmar, Nopens, Valérie, Vanhoorne, Bruno G, De Geest, Thomas, De Beer, Chris, Vervaet   +11 more
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On the Role of Aging, Washing, and Drying in the Synthesis of Polycrystalline Zinc Oxide by Precipitation: Combining Fast Continuous Mixing, Spray Drying and Freeze Drying to Unravel the Solid-State Transformations of the Precipitate

Catalysis Letters, 2008
The continuous precipitation of zinc carbonates using aqueous solutions of zinc nitrate and sodium carbonate was quenched within a few seconds by combining a micromixer with a bench-top spray dryer. In this way, it was possible to monitor the slow phase transformation of the initially formed sodium zinc carbonate into zinc hydroxy carbonate during ...
Kaluza, Stefan, Muhler, Martin
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Freeze-drying of suspended vials: a first step toward continuous manufacturing

2016
The new paradigm of pharmaceutical industry is to move from batch to continuous processes in order to satisfy the stringent requirements of quality, safety and efficiency set by regulatory authorities and reduce production costs. In this perspective, freeze-drying needs to be completely rethought in order to be more integrated in the chain of ...
CAPOZZI, LUIGI CARLO, PISANO, ROBERTO
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Continuous freeze drying

Vacuum, 1971
HAA Pyle, H Eilenberg
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Production of mouse fetuses using spermatozoa exposed temporarily to high temperature or continuously to room temperature after freeze-drying in Na+-free/K+-rich EGTA buffer

Cryobiology, 2019
Present study aimed to determine to what extent freeze-dried spermatozoa were able to withstand high-temperature conditions: transient increase in storage temperature and long-term exposure to room temperature. Mouse spermatozoa were freeze-dried in EGTA/Tris-HCl buffered solution alkalinized using KOH (K-ETBS, pH 7.7), and then stored for up to 7 ...
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