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Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing [PDF]
Advanced ScienceLyophilization (aka freeze drying) is a typical process in (bio)pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications to mRNA vaccines.
Prakitr Srisuma +2 more
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Transforming PRP into a Shelf-Stable therapy: Lyophilization preserves angiogenic and regenerative properties [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Platelet-rich plasma (PRP) is widely used in regenerative medicine due to its high concentration of bioactive growth factors; however, its short shelf life limits its clinical applicability.
Amin Solouki +4 more
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Hyperspectral Imaging Techniques for Lyophilization: Advances in Data‐Driven Modeling Strategies and Applications [PDF]
Advanced ScienceLyophilization, aka freeze drying, is a key process used in the production of biotherapeutic products. The optimization of lyophilization formulations and operations is a slow process that could be accelerated by on‐line analytics.
Huiwen Yu +5 more
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npj Vaccines, 2023 Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2–8 °C. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs).
Mingyuan Li +14 more
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Brazilian Journal of Pharmaceutical Sciences, 2023 The purpose of the present study was to develop stable lyophilized formulation of peginterferon alfa-2b which is acquiescent to the short lyophilization process.
Patel Chintan, Patel Gayatri
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Annals of Microbiology, 2022 Purpose Uridine diphosphate glucose pyrophosphorylase (UGPase) plays an important role in glucose metabolism, catalyzing the reversible formation and decomposition of UDP-glucose (UDPG).
Chaoran Xia +6 more
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Limited influence of marine sediment lyophilization on prokaryotic community structure assessed via amplicon sequencing: an example from environmentally contrasted sediment layers in Toulon harbor (France) [PDF]
PeerJ, 2021 Sediment lyophilization is a common process that allows for long-term conservation and sharing of marine sediments for multiple downstream analyses. Although it is often used for geochemical studies, the effects of lyophilization on prokaryotic taxonomic
Benjamin Misson +2 more
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Neural Regeneration Research, 2021 Both lyophilization and electrospinning are commonly used to make chitosan scaffolds. However, it remains unknown which method is better for cell growth. In this study, we established the following groups: (1) lyophilization group—chitosan scaffolds were
Yu-Xuan Wu +3 more
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Chinese Journal of Magnetic Resonance, 2020 Sample pretreatment is essential for metabonomic analysis. Lyophilization (freeze-drying) is widely used for sample pretreatment to remove solvent, especially water, prior to nuclear magnetic resonance (NMR) and/or mass spectrum (MS) analysis.
LIU Si, AN Yan-peng, TANG Hui-ru
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Lyophilization: The process and industrial use [PDF]
Hemijska Industrija, 2004 This article presents a general overview of lyophilization and discusses the underlying principles of the process through the basics of: formulation, freezing, primary drying and secondary drying.
Pržić Dejan S. +2 more
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