Results 41 to 50 of about 50,534 (301)
Lyophilization of Synthetic Gene Carriers
, 2019 Lyophilization, also known as freeze drying, is a widely used method for stabilization, improvement of long-term storage stability, and simplification of handling of drugs and/or carrier systems. Lyophilization is time-consuming and energy-consuming, and
Sarah Hedtrich +5 more
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FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing
Advanced ScienceLyophilization (aka freeze drying) is a typical process in (bio)pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications to mRNA vaccines.
Prakitr Srisuma +2 more
doaj +1 more source
Lyophilization of synthetic gene carriers
, 2013 Lyophilization, also known as freeze-drying, is a widely used method for stabilization, improvement of long-term storage stability, and simplification of the handling of drugs and/or carrier systems.
Küchler, S., Friess, W., Kasper, J.C.
core +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Lyophilization of CNBr-activated agarose beads with lactose and PEG
, 2009 CNBr-activated agarose beads (CAABs) have been considered as an important intermediate to derivate various versatile bio-separation media. Unfortunately, the highly reactive groups on the beads are liable to hydrolysis and therefore lyophilization is ...
Wang, Jia-Xing +4 more
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FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai +13 more
wiley +1 more source
Mechanisms of Damaging Bacteria during Lyophilization and Protective Activity of Shielding Media
Проблемы особо опасных инфекций, 2016 Considered are the current views on the mechanisms and factors of bacterial cell degradation during lyophilization and storage of dry preparations.
I. V. Gracheva, A. V. Osin
doaj +1 more source
From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics
Advanced Functional Materials, EarlyView.We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou +3 more
wiley +1 more source