Results 261 to 270 of about 223,531 (304)

The Impact of Formulation Composition and Process Settings of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation

Journal of Pharmaceutical Sciences, 2020
The long-term stability of therapeutic protein products can be extended by freeze-drying. However, the freeze-drying process itself has several harmful stresses. A rationalized formulation design can significantly mitigate protein damage caused by freezing, dehydration and interfacial stresses of lyophilization and reconstitution.
Brecht, Vanbillemont   +3 more
semanticscholar   +5 more sources

Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation

European Journal of Pharmaceutics and Biopharmaceutics, 2018
The continuous freeze-drying concept based on spinning the vials during freezing and on non-contact energy transfer via infrared (IR) radiation during drying, improves process efficiency and product quality (uniformity) compared to conventional batch freeze-drying. Automated control of this process requires the fundamental mechanistic modelling of each
Pieter-Jan, Van Bockstal   +6 more
semanticscholar   +5 more sources

From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses

Industrial & Engineering Chemistry Research, 2019
In response to the current trend in the pharmaceutical industry, a new concept for the freeze-drying of pharmaceuticals in unit-doses is presented: the continuous freeze-drying/lyophilization of su...
Luigi C. Capozzi   +2 more
openaire   +3 more sources

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