Results 271 to 280 of about 223,531 (304)

Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process

International Journal of Pharmaceutics, 2023
Continuous spin freeze-drying provides a range of opportunities regarding the implementation of several in-line process analytical technologies (PAT) to control and optimize the freeze-drying process at the individual vial level. In this work, two methods were developed to (1) control the freezing phase by separately controlling the cooling and ...
Laurens Leys, Gust Nuytten, Pieter-Jan Van Bockstal, Thomas De Beer   +3 more
openaire   +3 more sources

Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

Analytical Chemistry, 2018
Near-infrared chemical imaging (NIR-CI) is an emerging tool for process monitoring because it combines the chemical selectivity of vibrational spectroscopy with spatial information. Whereas traditional near-infrared spectroscopy is an attractive technique for water content determination and solid-state investigation of lyophilized products, chemical ...
Davinia Brouckaert, Laurens De Meyer, Brecht Vanbillemont, Pieter-Jan Van Bockstal, Joris Lammens, Séverine Mortier, Jos Corver, Chris Vervaet, Ingmar Nopens, Thomas De Beer   +9 more
openaire   +3 more sources

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

International Journal of Pharmaceutics, 2018
Recently, a continuous freeze-drying process for the production of unit doses was presented and evaluated. In this concept, the freezing step is modified compared to traditional batch freeze-drying, as glass vials filled with a liquid formulation, are rotated around their longitudinal axis while cooled and frozen with a cold, sterile and inert gas (i.e.
Joris, Lammens, Séverine Thérèse F C, Mortier, Laurens, De Meyer, Brecht, Vanbillemont, Pieter-Jan, Van Bockstal, Simon, Van Herck, Jos, Corver, Ingmar, Nopens, Valérie, Vanhoorne, Bruno G, De Geest, Thomas, De Beer, Chris, Vervaet   +11 more
openaire   +3 more sources

Evaluation of immersion‐contact type heat transfer for continuous pharmaceutical spin freeze‐drying process

Journal of Food Process Engineering, 2019
AbstractSpin freeze‐drying process is a recently proposed method to achieve continuous processing of unit doses in freeze‐drying application. An experimental study is carried out to investigate the heat transfer and drying characteristics of a spin‐frozen liquid product.
Ganeshmurthy Srinivasan, Balakrishnan Raja   +1 more
openaire   +2 more sources

Optimizing the secondary drying phase of a continuous Spin-Freeze Drying process: A semi-mechanistic modelling approach

International Journal of Pharmaceutics
Over the past decade, continuous spin freeze-drying technology has emerged as a promising alternative to conventional batch freeze-drying, effectively addressing many of the latter's inherent disadvantages. Much of the focus during this period has been on controlling and optimizing the primary drying phase of this process.
Laurens Leys, Thomas De Beer
openaire   +3 more sources

Potential application of infrared assisted freeze drying (IRAFD) for banana snacks: Drying kinetics, energy consumption, and texture

LWT - Food Science and Technology, 2019
Efficacy of infrared assisted freeze drying (IRAFD) was investigated to produce banana snacks. Infrared (IR) lamp was installed into freeze dryer. Various IRAFD trials including the continuous IRAFD-2.7 kW/m2, IRAFD-2.7 kW/m2 at 20% weight reduction (WR),
Apinya Khampakool, Salinee Soisungwan, S. Park   +2 more
semanticscholar   +3 more sources

A Directional Strain Sensor Based on Anisotropic Microhoneycomb Cellulose Nanofiber-Carbon Nanotube Hybrid Aerogels Prepared by Unidirectional Freeze Drying.

Small, 2019
Aerogels are one of the most popular composite reinforcement materials because of their high porosity and their continuous and homogeneous network. Most aerogels are isotropic, thus leading to isotropic composites when they are used as fillers.
Cong Wang, Zheng‐Ze Pan, Wei Lv, Bilu Liu, Jie Wei, Xiaohui Lv, Yi Luo, H. Nishihara, Quan-hong Yang   +8 more
semanticscholar   +3 more sources

Continuous freeze drying

Vacuum, 1971
HAA Pyle, H Eilenberg
openaire   +2 more sources

Continuous Freeze-Drying of Serratia marcescens

Industrial & Engineering Chemistry, 1958
H. G. Maister, E. N. Heger, W. M. Bogart
openaire   +2 more sources

Effects of continuous millifluidic process on the physicochemical properties and freeze-drying of cloxacillin benzathine-loaded nanocapsules

Journal of Drug Delivery Science and Technology
Douglas Gualberto Sales Pereira, Laura Cota Torquato, Maria Betânia de Freitas Marques, Carlos Alberto Senna, Rodrigo Prioli Menezes, Vanessa Carla Furtado Mosqueira, Raquel Silva Araújo   +6 more
openaire   +2 more sources