Results 271 to 280 of about 98,285 (300)

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

International Journal of Pharmaceutics, 2018
Recently, a continuous freeze-drying process for the production of unit doses was presented and evaluated. In this concept, the freezing step is modified compared to traditional batch freeze-drying, as glass vials filled with a liquid formulation, are rotated around their longitudinal axis while cooled and frozen with a cold, sterile and inert gas (i.e.
Joris, Lammens, Séverine Thérèse F C, Mortier, Laurens, De Meyer, Brecht, Vanbillemont, Pieter-Jan, Van Bockstal, Simon, Van Herck, Jos, Corver, Ingmar, Nopens, Valérie, Vanhoorne, Bruno G, De Geest, Thomas, De Beer, Chris, Vervaet   +11 more
openaire   +2 more sources

Optimizing the secondary drying phase of a continuous Spin-Freeze Drying process: A semi-mechanistic modelling approach

International Journal of Pharmaceutics
Over the past decade, continuous spin freeze-drying technology has emerged as a promising alternative to conventional batch freeze-drying, effectively addressing many of the latter's inherent disadvantages. Much of the focus during this period has been on controlling and optimizing the primary drying phase of this process.
Laurens Leys, Thomas De Beer
openaire   +2 more sources

On the Role of Aging, Washing, and Drying in the Synthesis of Polycrystalline Zinc Oxide by Precipitation: Combining Fast Continuous Mixing, Spray Drying and Freeze Drying to Unravel the Solid-State Transformations of the Precipitate

Catalysis Letters, 2008
The continuous precipitation of zinc carbonates using aqueous solutions of zinc nitrate and sodium carbonate was quenched within a few seconds by combining a micromixer with a bench-top spray dryer. In this way, it was possible to monitor the slow phase transformation of the initially formed sodium zinc carbonate into zinc hydroxy carbonate during ...
Kaluza, Stefan, Muhler, Martin
openaire   +2 more sources

Freeze-drying of suspended vials: a first step toward continuous manufacturing

2016
The new paradigm of pharmaceutical industry is to move from batch to continuous processes in order to satisfy the stringent requirements of quality, safety and efficiency set by regulatory authorities and reduce production costs. In this perspective, freeze-drying needs to be completely rethought in order to be more integrated in the chain of ...
CAPOZZI, LUIGI CARLO, PISANO, ROBERTO
openaire   +1 more source

Continuous freeze drying

Vacuum, 1971
HAA Pyle, H Eilenberg
openaire   +1 more source

Production of mouse fetuses using spermatozoa exposed temporarily to high temperature or continuously to room temperature after freeze-drying in Na+-free/K+-rich EGTA buffer

Cryobiology, 2019
Present study aimed to determine to what extent freeze-dried spermatozoa were able to withstand high-temperature conditions: transient increase in storage temperature and long-term exposure to room temperature. Mouse spermatozoa were freeze-dried in EGTA/Tris-HCl buffered solution alkalinized using KOH (K-ETBS, pH 7.7), and then stored for up to 7 ...
openaire   +2 more sources

Continuous Freeze-Drying of Serratia marcescens

Industrial & Engineering Chemistry, 1958
H. G. Maister, E. N. Heger, W. M. Bogart
openaire   +1 more source

Searches for continuous-wave gravitational radiation

Living Reviews in Relativity, 2023
Keith Riles
exaly  

On the continuous freeze-drying of coffee extract

Vacuum, 1968
openaire   +1 more source

Skin bioelectronics towards long-term, continuous health monitoring

Chemical Society Reviews, 2022
Yan Wang, Hossam Haick, Chunya Wang
exaly