Results 51 to 60 of about 766,211 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Differential Privacy Preservation for Location Semantics

open access: yesSensors, 2023
With the rapid development of intelligent mobile terminals and communication technologies, location-based services (LBSs) have become an essential part of users’ lives. LBS providers upload and share the collected users’ location data.
Liang Yan   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Exploration of location-based services adoption

open access: yes, 2014
The purpose of this paper is to explore aspects of user perceptions of their use of location-based services. As mobile technologies become more ubiquitous in the general population, it is reasonable to assume that individuals will consume services and ...
McKenna, Brad   +2 more
core   +1 more source

The Distribution System Design Problem Applying Real Settlement Data

open access: yesCommunications, 2001
The complicated way of obtaining true values of entry parameters is a weaker part of distribution system design problem. This paper uses a continuous approximation approach to identify an optimal number of terminals.
Lubos Buzna
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Privacy enhancing method for dummy-based privacy protection with continuous location-based service queries

open access: yesTongxin xuebao, 2016
Without need for the third party and sharing key, the dummy-based privacy protection scheme enabled users to obtain the precise query result in location-based services.
Hai LIU   +3 more
doaj   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Effect of intermediate supports location on natural frequencies of multiple cracked continuous beams

open access: yesVietnam Journal of Mechanics, 2018
The present paper deals with free vibration of multiple cracked continuous beams with intermediate rigid supports. A simplified method is proposed to obtain general solution of free vibration in cracked beam with intermediate supports that is then used ...
Do Nam   +4 more
doaj   +1 more source

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