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Continuous Feeding-Blending in Pharmaceutical Continuous Manufacturing
2020Pharmaceutical continuous manufacturing has steadily progressed from the proof of concept to the pilot and industrial production in the past two decades, some of which have recently been approved by the US Food and Drug Administration (FDA), resulting in a greater demand on experience in process design and operation in pharmaceutical continuous ...
Qinglin Su +2 more
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Inter-plant Storage in Continuous Manufacturing
Technometrics, 1960A continuously operating plant A feeds its product into storage which in turn feeds a second continuously operating plant B. The loss of production due to empty or full storage depends on the storage capacity. This dependence is examined by treating the fluctuating storage content as a finite Markov chain, as in P. A. P.
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Sensor Network for Continuous Tablet Manufacturing
2018The progress in the mechanistic understanding of the unit operations and the availability of multiple sensor technologies enable the inline implementation of data reconciliation and gross error detection methods in continuous pharmaceutical manufacturing. In this work, we demonstrate the benefits of accurate real-time monitoring of the process state in
Sudarshan, Ganesh +5 more
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Optimal Campaign Continuous Manufacturing
Industrial & Engineering Chemistry Research, 2015Campaign continuous manufacturing (CM), characterized by relatively short operational windows such as a few weeks, is being explored as an alternative to traditional batch-wise manufacturing in the pharmaceutical industry. However, optimal operation in campaign CM can be challenging because of the significance of startup and shutdown phases, which can ...
Ali M. Sahlodin, Paul I. Barton
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Continuous manufacturing of viral particles
Current Opinion in Chemical Engineering, 2018Cell-based production of viral particles has gain interest in the last years due to promising therapeutic applications. In the field of vaccination, novel vaccines are required to face the new pathogen outbreaks, and rapid and more efficient processes are required to respond as fast as possible to the vaccination demand worldwide.
Sonia Gutiérrez-Granados +2 more
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Continuous Reactors for Pharmaceutical Manufacturing
2020A variety of high-pressure and low-pressure plug flow reactors (PFRs) are described in this chapter with manufacturing examples for each. Coiled tube PFRs and vertical pipes-in-series PFRs were used for two-phase gas–liquid reactions. A pulsating flow coiled tube PFR was used for gas–liquid reaction with solids precipitate.
Martin D. Johnson +8 more
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Continuous Manufacturing Processes
1982The rapidly expanding usage of composite components in automotive and other mass production industries has focused attention on continuous production techniques as they apply to these engineering materials. It is recognized that where product volume warrants, a continuous processing system from raw material to finished product approaches optimum ...
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Continuous improvement in British manufacturing
Technovation, 1993Abstract Continuous improvement (CI) — sustained, focused, company-wide incremental innovation — is increasingly recognized as a powerful potential source of competitive advantage. Experience — particularly but not exclusively in Japan — suggests that major gains in quality, flexibility and cost saving can result from CI programmes, and as a result ...
John Bessant +3 more
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Basic Principles of Continuous Manufacturing
2020Continuous manufacturing in the pharmaceutical industry is an emerging technology, although it is widely practiced in industries such as petrochemical, bulk chemical, foods, and mineral processing. This chapter briefly discusses the characteristics of continuous manufacturing at the conceptual level, first, in its generic form, viewing the process as a
Sudarshan Ganesh, Gintaras V. Reklaitis
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