The Influence of Wet Granulation Parameters on the Compaction Behavior and Tablet Strength of a Hydralazine Powder Mixture [PDF]
Pharmaceutics, 2023 The aim of this paper was to describe the influence of high-shear wet granulation process parameters on tablet tensile strength and compaction behavior of a powder mixture and granules containing hydralazine.
Oliver Macho +6 more
doaj +4 more sources
Wet granulation: the effect of shear on granule properties [PDF]
Powder Technology, 2003 This paper presents a study of the wet granulation of fine cosmetic particles using a high-shear mixer granulator on a given particle and binder system. The shear effect on granule properties is highlighted. The granules formed under different impeller speeds are divided into size classes and further examined in terms of porosity, friability and binder
J A Dodds
exaly +4 more sources
Evaluation of Binders in Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL-SFP, HPC SSL, and HPC SL-FP) were evaluated regarding their suitability in twin-screw wet granulation.
Claudia Köster +2 more
doaj +5 more sources
Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing [PDF]
Pharmaceutics, 2023 The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster +4 more
doaj +2 more sources
Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation [PDF]
Pharmaceutics, 2023 (1) Background: Amorphous drug systems are an intensively studied approach to overcome the insufficient bioavailability of poorly soluble drugs. Here, paper tablets were studied, which were made from cellulose-based paper matrices loaded with norfloxacin.
Lara Heidrich +5 more
doaj +2 more sources
Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation. [PDF]
PLoS ONE, 2021 High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally optimized by hit and trial which involves preparation of granules under different processing ...
Amjad Khan
doaj +4 more sources
Improved wet granulation techniques [PDF]
Farmacja Polska, 2020 Wet granulation is one of the most frequently used processes in the pharmaceutical industry to manufacture solid dosage forms. Wet granulation is helpful in tableting active substances that are not susceptible to the compression.
Monika Pastewska, Wiesław Sawicki
doaj +2 more sources
Effect of operating conditions and physico–chemical properties on the wet granulation kinetics in high shear mixer [PDF]
, 2009 The wet granulation process is sensitive to changes in product properties and process variables. The optimal process and formulation are based on the knowledge of the granule growth mechanisms and of the effects of product properties and process ...
Benali, Mohammed +2 more
core +3 more sources
Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation [PDF]
Pharmaceutics, 2022 Pellet production is a multi-step manufacturing process comprising granulation, extrusion and spheronisation. The first step represents a critical control point, since the quality of the granule mass highly influences subsequent process steps and ...
Selina Ramm +5 more
doaj +2 more sources
Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids [PDF]
Pharmaceutics, 2021 The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules.
Ryoma Tanaka +5 more
doaj +2 more sources