Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process [PDF]
Pharmaceutics, 2021 The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere +7 more
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Microwave-Assisted Wet Granulation for Engineering Rice Starch–Mannitol Co-Processed Excipients for Direct Compression of Orally Disintegrating Tablets [PDF]
PharmaceuticsBackground/Objectives: Enhancing excipient functionality through environmentally friendly and scalable processing methods is essential for improving the manufacturability and performance of orally disintegrating tablets (ODTs).
Karnkamol Trisopon, Phennapha Saokham
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Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 Experimental characterization of solid-liquid mixing for a high shear wet granulation process in a twin-screw granulator (TSG) is very challenging. This is due to the opacity of the multiphase system and high-speed processing.
Ashish Kumar +4 more
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Parametric Study of Residence Time Distributions and Granulation Kinetics as a Basis for Process Modeling of Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 Twin-screw wet granulation is a crucial unit operation in shifting from pharmaceutical batch to continuous processes, but granulation kinetics as well as residence times are yet poorly understood.
Timo Plath +3 more
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Amorphous and Co-Amorphous Olanzapine Stability in Formulations Intended for Wet Granulation and Pelletization. [PDF]
Int J Mol Sci, 2022 da Costa NF +3 more
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Selection of disintegrants for wet granulation method of “Angiolin” tablets
Zaporožskij Medicinskij Žurnal, 2016 Every year there are about 9.4 million people who die from cardiovascular diseases. Among them, 51% of people are dying from stroke, and 45 % – from coronary heart disease.
I. A. Mazur +3 more
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Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis [PDF]
Pharmaceutics, 2021 Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing.
Ana Alejandra Barrera Jiménez +4 more
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Characterizing a design space for a twin-screw wet granulation process: A case study of extended-release tablets. [PDF]
Int J Pharm, 2023 Sierra-Vega NO +4 more
europepmc +3 more sources
DEM modeling of high shear wet granulation of a simple system [PDF]
Asian Journal of Pharmaceutical Sciences, 2018 High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with ...
Saurabh Sarkar, Bodhisattwa Chaudhuri
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Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process [PDF]
International Journal of Pharmaceutics: XIn pharmaceutical manufacturing, integrating model-based design and optimization can be beneficial for accelerating process development. This study explores the utilization of Machine Learning (ML) techniques as a surrogate model for the optimization of ...
Ashley Dan, Rohit Ramachandran
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