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Continuous Reactors for Pharmaceutical Manufacturing
2020A variety of high-pressure and low-pressure plug flow reactors (PFRs) are described in this chapter with manufacturing examples for each. Coiled tube PFRs and vertical pipes-in-series PFRs were used for two-phase gas–liquid reactions. A pulsating flow coiled tube PFR was used for gas–liquid reaction with solids precipitate.
Martin D. Johnson +8 more
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Continuous manufacturing of viral particles
Current Opinion in Chemical Engineering, 2018Cell-based production of viral particles has gain interest in the last years due to promising therapeutic applications. In the field of vaccination, novel vaccines are required to face the new pathogen outbreaks, and rapid and more efficient processes are required to respond as fast as possible to the vaccination demand worldwide.
Sonia Gutiérrez-Granados +2 more
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Sensor Network for Continuous Tablet Manufacturing
2018The progress in the mechanistic understanding of the unit operations and the availability of multiple sensor technologies enable the inline implementation of data reconciliation and gross error detection methods in continuous pharmaceutical manufacturing. In this work, we demonstrate the benefits of accurate real-time monitoring of the process state in
Sudarshan, Ganesh +5 more
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Inter-plant Storage in Continuous Manufacturing
Technometrics, 1960A continuously operating plant A feeds its product into storage which in turn feeds a second continuously operating plant B. The loss of production due to empty or full storage depends on the storage capacity. This dependence is examined by treating the fluctuating storage content as a finite Markov chain, as in P. A. P.
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Continuous Manufacturing Processes
1982The rapidly expanding usage of composite components in automotive and other mass production industries has focused attention on continuous production techniques as they apply to these engineering materials. It is recognized that where product volume warrants, a continuous processing system from raw material to finished product approaches optimum ...
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Throughput Optimization of Continuous Biopharmaceutical Manufacturing Facilities
PDA Journal of Pharmaceutical Science and Technology, 2016In order to operate profitably under different product demand scenarios, biopharmaceutical companies must design their facilities with mass output flexibility in mind. Traditional biologics manufacturing technologies pose operational challenges in this regard due to their high costs and slow equipment turnaround times, restricting the types of products
Fernando A, Garcia, Michael W, Vandiver
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Basic Principles of Continuous Manufacturing
2020Continuous manufacturing in the pharmaceutical industry is an emerging technology, although it is widely practiced in industries such as petrochemical, bulk chemical, foods, and mineral processing. This chapter briefly discusses the characteristics of continuous manufacturing at the conceptual level, first, in its generic form, viewing the process as a
Sudarshan Ganesh, Gintaras V. Reklaitis
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Achieving continuous manufacturing in lyophilization: Technologies and approaches
European Journal of Pharmaceutics and Biopharmaceutics, 2019This paper provides an organic overview of the most interesting continuous freeze-drying concepts that have been proposed over the years. Attention has mainly been focused on the field of pharmaceuticals, but some background has also been given on the food industry.
Pisano R. +3 more
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Regulatory Considerations for Continuous Manufacturing
2020This chapter assesses the current regulatory environment, including the relevant regulations and guidelines, and their impact on continuous manufacturing. It outlines key regulatory aspects, including continuous manufacturing process description, control strategy, process validation, and key GMP requirements.
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