Results 211 to 220 of about 5,232,603 (249)

Achieving continuous manufacturing in lyophilization: Technologies and approaches

European Journal of Pharmaceutics and Biopharmaceutics, 2019
This paper provides an organic overview of the most interesting continuous freeze-drying concepts that have been proposed over the years. Attention has mainly been focused on the field of pharmaceuticals, but some background has also been given on the ...
Roberto Pisano, Luigi C Capozzi, Bernhardt L. Trout   +2 more
exaly   +2 more sources

Continuous Manufacturing of Pharmaceutical Products: A Density-Insensitive Near Infrared Method for the In-line Monitoring of Continuous Powder Streams.

International journal of pharmaceutics, 2023
Near infrared (NIR) spectroscopy is a valuable analytical technique for monitoring chemical composition of powder blends in continuous pharmaceutical processes.
Natasha L. Velez-Silva, J. Drennen, Carl A. Anderson   +2 more
semanticscholar   +1 more source

Continuous Manufacturing of Active Pharmaceutical Ingredients: Current Trends and Perspectives

Advanced Synthesis & Catalysis, 2023
The pharmaceutical industry has traditionally employed batch processing as a means of synthesizing active pharmaceutical ingredients (APIs) on a commercial scale. Batch manufacturing enables API synthesis in large quantities in order to meet regulations.
Andres P. Hyer, Daniel G. Gregory, Quang Le, Kaitlin E. Kay, Justin T. Turnage, B. F. Gupton, James K. Ferri   +6 more
semanticscholar   +1 more source

Integrated continuous manufacturing of inhalable remdesivir nanoagglomerate dry powders: design, optimization and therapeutic potential for respiratory viral infections.

International journal of pharmaceutics, 2023
While inhalable nanoparticle-based dry powders have demonstrated promising potential as next-generation respiratory medicines, erratic particle redispersibility, and poor manufacturing reproducibility remain major hurdles hindering their translation from
Ho-Wan Chan, Hok-Wai Lee, Stephanie Chow, David Chi Leung Lam, Shing-Fung Chow   +4 more
semanticscholar   +1 more source

Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions

AAPS PharmSciTech, 2022
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-soluble drugs. The escalating number of drugs with poor aqueous solubility, poor dissolution, and poor oral bioavailability is an unresolved problem that requires ...
Amritha G Nambiar, Maaninder Singh, Abhishek R. Mali, D. R. Serrano, Rajnish Kumar, A. Healy, A. Agrawal, Dinesh Kumar   +7 more
semanticscholar   +1 more source

Challenges, Opportunities and Recent Advances in Near Infrared Spectroscopy Applications for Monitoring Blend Uniformity in the Continuous Manufacturing of Solid Oral Dosage Forms.

International journal of pharmaceutics, 2022
Near infrared (NIR) spectroscopy has been widely recognized as a powerful PAT tool for monitoring blend uniformity in continuous manufacturing (CM) processes.
Natasha L. Velez, J. Drennen, C. Anderson   +2 more
semanticscholar   +1 more source

Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transition from batch to continuous

Biotechnology progress (Print), 2022
Implementation of continuous in lieu of batch upstream processing (USP) and downstream process (DSP) for the production of recombinant therapeutic protein is a significant paradigm change.
Kevin Botelho Ferreira, Asma Benlegrimet, Gabriel Diane, Victor Pasquier, R. Guillot, Marc De Poli, Loïc Chappuis, N. Vishwanathan, J. Souquet, H. Broly, Jean-Marc Bielser   +10 more
semanticscholar   +1 more source

Benchtop NIR Method Development for Continuous Manufacturing Scale to Enable Efficient PAT Application for Solid Oral Dosage Form.

International journal of pharmaceutics, 2021
A Near Infrared (NIR) method was developed using a small benchtop feed frame system to quantify Saccharin potency in a powder blend during continuous manufacturing process.
Md Anik Alam, Yang Angela Liu, Stephanie Dolph, Marcin Pawliczek, E. Peeters, Andrew S. Palm   +5 more
semanticscholar   +1 more source

Continuous manufacturing versus batch manufacturing: benefits, opportunities and challenges for manufacturers and regulators

, 2021
Continuous manufacturing (CM) is the integration of a series of unit operations, processing materials continually to produce the final pharmaceutical product.
S. Hock, Teh Kee Siang, L. Chan
semanticscholar   +1 more source

Development and Scale-Up of a Continuous Manufacturing Process for a Hydrazine Condensation Reaction

, 2021
The development of a continuous manufacturing process for a hydrazine condensation reaction at high temperature is reported.
Rui-li Zhu, R. Reddy, Man Ding, Ming Xu, Chao Deng, Sam Tadayon, Hui Li, K. Depew, B. S. Lane   +8 more
semanticscholar   +1 more source