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The Rocky Road From Fed-Batch to Continuous Processing With E. coli [PDF]
Frontiers in Bioengineering and Biotechnology, 2019 Escherichia coli still serves as a beloved workhorse for the production of many biopharmaceuticals as it fulfills essential criteria, such as having fast doubling times, exhibiting a low risk of contamination, and being easy to upscale.
Julian Kopp +4 more
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The Rocky Road to a Digital Lab
CHIMIA, 2023 The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs).
Peter Sagmeister +2 more
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Advances in Twin-Screw Granulation Processing
Pharmaceutics, 2021 Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms.
Uttom Nandi +3 more
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Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products
Pharmaceutics, 2021 This article highlights the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion. The different melt granulation process options and excipients are described and compared, and a case is made for expanded use of twin-screw melt
Seth P. Forster +2 more
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Pharmaceutics, 2022 Replacing batch unit operations of biopharmaceuticals by continuous manufacturing is a maturing concept, with periodic counter-current chromatography (PCC) favoured to replace batch chromatography.
João P. Mendes +5 more
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Flow Map for Hydrodynamics and Suspension Behavior in a Continuous Archimedes Tube Crystallizer
Crystals, 2021 The Archimedes Tube Crystallizer (ATC) is a small-scale coiled tubular crystallizer operated with air-segmented flow. As individual liquid segments are moved through the apparatus by rotation, the ATC operates as a pump.
Jana Sonnenschein +5 more
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Membranes, 2023 Recent approval of several viral-vector-based therapeutics has led to renewed interest in the development of more efficient bioprocessing strategies for gene therapy products.
Akshay S. Chaubal, Andrew L. Zydney
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Current Opinion in Physiology, 2020 Speech processing in the human brain is grounded in non-specific auditory processing in the general mammalian brain, but relies on human-specific adaptations for processing speech and language. For this reason, many recent neurophysiological investigations of speech processing have turned to the human brain, with an emphasis on continuous speech ...
Christian Brodbeck, Jonathan Z Simon
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Frontiers in Chemical Engineering, 2023 Single-pass tangential flow filtration (SPTFF) is a crucial technology enabling the continuous manufacturing of monoclonal antibodies (mAbs). By significantly increasing the membrane area utilized in the process, SPTFF allows the mAb process stream to be
Naveen G. Jesubalan +3 more
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Continuous Melt Granulation for Taste-Masking of Ibuprofen
Pharmaceutics, 2021 Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be challenging and require complex manufacturing approaches. The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin ...
Seth P. Forster, David B. Lebo
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