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CHIMIA, 2023
The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs).
Peter Sagmeister, Jason D. Williams, C. Oliver Kappe +2 more
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Advances in Twin-Screw Granulation Processing

Pharmaceutics, 2021
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms.
Uttom Nandi +3 more
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Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products

Pharmaceutics, 2021
This article highlights the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion. The different melt granulation process options and excipients are described and compared, and a case is made for expanded use of twin-screw melt
Seth P. Forster, Erin Dippold, Tiffany Chiang +2 more
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Continuous Melt Granulation for Taste-Masking of Ibuprofen

Pharmaceutics, 2021
Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be challenging and require complex manufacturing approaches. The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin ...
Seth P. Forster, David B. Lebo
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Comparative investigation on the value-added products obtained from continuous and batch hydrothermal liquefaction of sewage sludge

Frontiers in Environmental Science, 2022
Hydrothermal liquefaction (HTL) can be considered a promising route for the energy valorisation of waste sewage sludge (SS). However, not much information is available on continuous flow processing. In this study, the mixed SS was subjected to HTL at 350°
Yujie Fan +6 more
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Continuous Affinity Purification of Adeno-Associated Virus Using Periodic Counter-Current Chromatography

Pharmaceutics, 2022
Replacing batch unit operations of biopharmaceuticals by continuous manufacturing is a maturing concept, with periodic counter-current chromatography (PCC) favoured to replace batch chromatography.
João P. Mendes +5 more
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Flow Map for Hydrodynamics and Suspension Behavior in a Continuous Archimedes Tube Crystallizer

Crystals, 2021
The Archimedes Tube Crystallizer (ATC) is a small-scale coiled tubular crystallizer operated with air-segmented flow. As individual liquid segments are moved through the apparatus by rotation, the ATC operates as a pump.
Jana Sonnenschein +5 more
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Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications

Membranes, 2023
Recent approval of several viral-vector-based therapeutics has led to renewed interest in the development of more efficient bioprocessing strategies for gene therapy products.
Akshay S. Chaubal, Andrew L. Zydney
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Deep neural network for prediction and control of permeability decline in single pass tangential flow ultrafiltration in continuous processing of monoclonal antibodies

Frontiers in Chemical Engineering, 2023
Single-pass tangential flow filtration (SPTFF) is a crucial technology enabling the continuous manufacturing of monoclonal antibodies (mAbs). By significantly increasing the membrane area utilized in the process, SPTFF allows the mAb process stream to be
Naveen G. Jesubalan +3 more
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Towards high mechanical performance Al–Cu–Mg–Fe–Ni alloy: influence of composition, solution treatment and aged process on microstructural evolution and mechanical properties

Journal of Materials Research and Technology, 2023
Al–Cu–Mg–Fe–Ni alloys are widely used in high temperature structural materials such as automobile engine cylinders and pistons, owning to their good high temperature mechanical properties.
Zhou Yang +7 more
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flow chemistry
twin-screw granulation