Results 71 to 80 of about 728,067 (268)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

High-strength cellulose nanofiber/graphene oxide hybrid filament made by continuous processing and its humidity monitoring. [PDF]

Sci Rep, 2021
Kim HC, Panicker PS, Kim D, Adil S, Kim J.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Advancing Monoclonal Antibody Manufacturing: Process Optimization, Cost Reduction Strategies, and Emerging Technologies

Biologics: Targets & Therapy
Ranjit Ranbhor Pergament & Cepeda LLC, Florham Park, NJ, 07932, USACorrespondence: Ranjit Ranbhor, Pergament & Cepeda LLC, Florham Park, NJ, 07932, USA, Tel +1 973 967 0490, Email ranjitranbhor@gmail.comPurpose: This review examines recent advances in ...
Ranbhor R
doaj  

Efficient Continuous Skyline Query Processing in Wireless Sensor Networks

Sensors, 2019
Owing to the rapid advent of wireless technology and proliferation of smart sensors, wireless sensor networks (WSNs) have been widely used to monitor and query the physical world in many applications based on the Internet of Things (IoT), such as ...
Yingyuan Xiao, Xu Jiao, Hongya Wang, Ching-Hsien Hsu, Li Liu, Wenguang Zheng   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Optomechanical circuits for nanomechanical continuous variable quantum state processing

New Journal of Physics, 2012
We propose and analyze a nanomechanical architecture where light is used to perform linear quantum operations on a set of many vibrational modes. Suitable amplitude modulation of a single laser beam is shown to generate squeezing, entanglement and state ...
Michael Schmidt, Max Ludwig, Florian Marquardt   +2 more
doaj   +1 more source

Accidental Continuous Releases from Coal Processing in Semi-Confined Environment

Energies, 2013
Notwithstanding the enforcement of ATEX EU Directives (94/9/EC of 23 March 1994) and safety management system application, explosions in the coal sector still claim lives and cause huge economic losses.
Bruno Fabiano, Emilio Palazzi, Fabio Currò   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source