Results 71 to 80 of about 4,751,282 (207)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Capturing Data Uncertainty in High-Volume Stream Processing [PDF]
, 2009 We present the design and development of a data stream system that captures data uncertainty from data collection to query processing to final result generation.
Liu, Anna +8 more
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Spline kernels for continuous-space image processing [PDF]
We present an explicit formula for spline kernels; these are defined as the convolution of several B-splines of variable widths h and degrees n. The spline kernels are useful for continuous signal processing algorithms that involve B-spline inner ...
Munoz, Arrate +7 more
core +2 more sources
CrystalsLayered double hydroxides (LDHs) are a vital tool in many different areas, such as drug delivery, catalysis, anion exchange (materials), polymer processing, etc. Conventionally, LDHs are synthesized in a batch process that consists of particle generation
Stefan Höving +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Efficient Continuous Skyline Query Processing in Wireless Sensor Networks
Sensors, 2019 Owing to the rapid advent of wireless technology and proliferation of smart sensors, wireless sensor networks (WSNs) have been widely used to monitor and query the physical world in many applications based on the Internet of Things (IoT), such as ...
Yingyuan Xiao +5 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Distributed processing of continuous spatiotemporal queries over road networks
Alexandria Engineering Journal, 2012 This paper presents a distributed algorithm for processing continuous spatiotemporal queries. Distributed query processing that involve multiple servers is inspired by (1) the need for scalability in terms of supporting a large number of moving objects ...
Asmaa Sallam +3 more
doaj +1 more source