Results 71 to 80 of about 583,715 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Comparing levels of organizational learning maturity of colleges and universities participating in traditional and non-traditional (Academic Quality Improvement Project) accreditation processes [PDF]

, 2001
Plan BBusiness and industry has successfully embraced the philosophy of organizational learning as tool to achieve its goals and strategic priorities. The purpose of this study is to compare the levels of organizational learning maturity of colleges and ...
Neefe, Diane Osterhaus
core  

Continuous Improvement Through Integration of Quality Tools

, 2002
Continuous quality improvement is now the focus of research and application in quality engineering. To achieve continuous improvement, it’s necessary to integrate quality tools and to plan, design and control the whole process of creating quality.
Zixian Liu, Zhen He, Ershi Qi
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

EVALUASI PROGRAM CHAMPIONSHIP SEBAGAI BENTUK CONTINUOUS QUALITY IMPROVEMENT (CQI) [PDF]

, 2013
Continuous Quality Improvement (CQI) is needed to fulfill customer need on health care services. Unfortunately, there was inconsistency between Championship Program implementation and long-term quality improvement program in Surabaya Oncology Hospital.
Nyoman Anita Damayanti, Dina Ribka Wijayanti   +1 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Factors Affecting the Implementation of Continuous Quality Improvement in Health Facilities in Southern Nation and Nationalities Peoples Region (SNNPR), Ethiopia

Journal of Multidisciplinary Healthcare, 2020
Nebiyou Wendwessen,1 Teklemariam Dereje,2 Addisu Gize3 1Institute for Health Care Improvement, Addis Ababa, Ethiopia; 2Department of Development Economics and Management, CFMD, Ethiopian Civil Service University, Addis Ababa, Ethiopia; 3Department of ...
Wendwessen N, Dereje T, Gize A
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