Results 71 to 80 of about 957,877 (266)

Finite Element Approximation of Variational Inequalities: An Algorithmic Approach

open access: yesSultan Qaboos University Journal for Science, 2018
In this paper, we introduce a new method to analyze the convergence of the standard finite element method for elliptic variational inequalities with noncoercive operators (VI).
Messaoud Boulbrachene
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Relaxation and weak solutions of nonlocal semilinear evolution systems

open access: yesAdvances in Difference Equations, 2019
We give a relatively short proof of the fact that the solution set of a nonlocal semilinear differential inclusion is dense in the weak solution set of the corresponding convexified system.
N. Javaid   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Developing a continuous flow-square wave voltammetry method for determination of atrazine in soil solutions using the hanging mercury drop electrode

open access: yesJournal of the Brazilian Chemical Society, 2006
This work describes the development of a Continuous Flow-Square Wave Voltammetry method for determination of atrazine using the hanging mercury drop electrode.
Santos Luciana B. O. dos   +2 more
doaj  

Prevention of halfway cracks in continuous cast A36 steel slabs containing boron [PDF]

open access: yesChina Foundry, 2015
The formation of halfway cracks in continuous cast A36 steel slabs containing 17 ppm boron was studied by investigating the zero ductility temperature (ZDT), zero strength temperature (ZST), solidification characteristics, and strain distribution in the ...
Jian-chao Ma, Qing-feng Zhou, Du-xing Su
doaj  

ON PROBLEM OF REGIONAL WAREHOUSE AND TRANSPORT INFRASTRUCTURE OPTIMIZATION

open access: yesНаука и техника, 2017
The article suggests an approach of solving the problem of warehouse and transport infrastructure optimization in a region. The task is to determine the optimal capacity and location of the support network of warehouses in the region, as well as power ...
I. Yu. Miretskiy   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

A Cauchy integral method to solve the 2D Dirichlet and Neumann problems for irregular simply-connected domains

open access: yesУчёные записки Казанского университета: Серия Физико-математические науки, 2018
A method for construction of solutions to the continuous approximate 2D Dirichlet and Neumann problems in the arbitrary simply-connected domain with a smooth boundary has been discussed.
A. El-Shenawy, E.A. Shirokova
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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