Results 81 to 90 of about 957,877 (266)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Optimization Problems with Averaging over the Variables
Моделирование и анализ информационных систем, 2017 The problems of nonlinear programming, criteria and limitations depend on the variables averaged. It is shown that if these problems have solutions, the Lagrangian reaches the maximum for the variables, which are averaged.
Anatoly M. Tsirlin
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Analytical Solution of Sand-drained Ground Consolidation Based on Continuous Drainage Boundary
工程科学与技术, 2019 For the limitations of the boundary condition under instantaneous constant load in traditional sand-drained consolidation theory, the three-dimensional consolidation equation of sand-drained ground was solved based on the continuous drainage boundary ...
Yi ZHANG +3 more
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Fuzzy Volterra Integral Equations with Piecewise Continuous Kernels: Theory and Numerical Solution
Известия Иркутского государственного университета: Серия "Математика"This research focuses on addressing both linear and nonlinear fuzzy Volterra integral equations that feature piecewise continuous kernels. The problem is tackled using the method of successive approximations.
S. Noeiaghdam +2 more
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Mixed and Continuous Strategy Monitor-Forward Game Based Selective Forwarding Solution in WSN
International Journal of Distributed Sensor Networks, 2015 Wireless sensor networks are often deployed in unattended and hostile environments. Due to the resource limitations and multihop communication in WSN, selective forwarding attacks launched by compromised insider nodes are a serious threat.
Hongmei Liao, Shifei Ding
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source