Results 241 to 250 of about 35,220 (306)
C/EBP α is Essential for Gonadal but Not Inguinal White Adipose Tissue Formation in Mice
Obesity, Volume 34, Issue 4, Page 882-895, April 2026.Human genetics has linked the gene CEBPA to waist to hip ratio and adipose distribution. We generated mice with AdipoQ‐Cre driven deletion of Cebpa and found these mice to have a specific reduction in gonadal white adipose tissue and myriad other metabolic phenotypes.
Krista Y. Hu +10 more
wiley +1 more source
Obesity, Volume 34, Issue 4, Page 851-870, April 2026.Guidance recommendations by TOS/OMA/OAC for the use of obesity medications to treat obesity and its complications. ABSTRACT Background Obesity affects over 40% of US adults, with severe obesity on the rise. Despite recognition of obesity as a chronic disease, it remains underdiagnosed and undertreated.
Lydia Alexander +12 more
wiley +1 more source
AI‐assisted design of a VEGFR2 agonistic peptide that promotes angiogenesis and wound repair
Protein Science, Volume 35, Issue 4, April 2026.Abstract Vascular endothelial growth factor (VEGF) serves as a principal regulator of neovascularization and is essential for vascular regeneration. In this study, we identified and evaluated VEGF Mimetic Peptide3 (VMP3), a novel synthetic peptide developed as a potential VEGFR‐2/VEGF‐A modulator.
Farzana Yasmeen +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.RUVBL2 mediates stress granule aggregation by regulating microglial metabolic reprogramming, thereby exacerbating postoperative delirium in aged rats with mild cognitive impairment. ABSTRACT Postoperative delirium (POD) accelerates the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) in elderly patients.
Lin Zhang +9 more
wiley +1 more source
Diabetic Medicine, Volume 43, Issue 4, April 2026.Abstract Background Despite advancements in diabetes management technologies, restrictions on insulin‐treated pilots persist, underscoring the need to evaluate the safety, efficacy and performance of these technologies in aviation settings. This systematic review aims to summarize the available evidence on the performance, safety and effectiveness of ...
Renald Meçani +11 more
wiley +1 more source
Model Predictive Control Algorithms for Pen and Pump Insulin Administration [PDF]
, 2012 Boiroux, Dimitri
core
Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2744-2756, April 2026.Abstract Aims Imeglimin is a novel oral hypoglycemic agent approved for the treatment of type 2 diabetes in Japan, with dual actions to enhance insulin secretion and improve insulin sensitivity, suggested by preclinical evidence. However, the effect of imeglimin on tissue‐specific insulin sensitivity and glucose kinetics using glucose tracers is ...
Tsubasa Tajima +10 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2594-2614, April 2026.Abstract Glucocorticoids (GCs) are widely utilised for the treatment of inflammatory and autoimmune conditions but often precipitate significant hyperglycaemia. People with type 1 diabetes (PWT1D) may be particularly affected due to the challenges of adjusting insulin dosing, for which recommendations remain unclear.
Alexandra Katz +8 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3238-3244, April 2026.Abstract Aims Impaired insulin sensitivity is an under‐recognised risk in Type 1 diabetes but is challenging to measure with ‘gold‐standard’ euglycaemic clamps. Adding stable‐isotope glucose distinguishes hepatic and muscle insulin action (assessed by endogenous glucose production [EGP] and glucose infusion rate [GIR], respectively).
Andrzej S. Januszewski +6 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3254-3263, April 2026.Abstract Aims Sotagliflozin, an inhibitor of sodium‐glucose co‐transporter (SGLT)‐1 and 2, reduces albuminuria, slows GFR decline, and may have diuretic and osmoregulatory effects. The effect of sotagliflozin added to insulin was assessed on markers of neurohormone activation and volume homeostasis in patients with type 1 diabetes (T1D).
Massimo Nardone +6 more
wiley +1 more source