Results 51 to 60 of about 259,977 (295)

Discovery of the Postcoital Contraceptive Effect of Rhus pentaphylla in a Study of Acute, Subchronic, and Neurodevelopmental Toxicity of Ethanolic Leaf Extract

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT In the present study, the acute, subchronic, and neurodevelopmental toxicity of Rhus pentaphylla, a Moroccan medicinal plant, was investigated in Swiss albino mice. HPLC analysis showed the presence of phenolic compounds with rutin as the principal component.
Fatimazahra Agouram   +4 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan   +6 more
wiley   +1 more source

Migration Experiences and Reported Sexual Behavior Among Young, Unmarried Female Migrants in Changzhou, China. [PDF]

open access: yes, 2017
BackgroundChina has a large migrant population, including many young unmarried women. Little is known about their sexual behavior, contraceptive use, and risk of unintended pregnancy.Methods475 unmarried female migrants aged 15-24, working in 1 of 6 ...
Hearst, Norman   +5 more
core   +1 more source

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman   +3 more
wiley   +1 more source

Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post‐Kala‐Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Post‐kala‐azar dermal leishmaniasis (PKDL) involves a high macrophage burden in which the Leishmania parasites reside. Liposomal amphotericin B (LAmB) plays a key role in the treatment of PKDL. The mononuclear phagocyte system (MPS) is crucial in the distribution of liposomal drugs as well as the leishmaniasis pathophysiology.
Wan‐Yu Chu   +12 more
wiley   +1 more source

Factors associated with crisis pregnancies in Ireland: Findings from three nationally representative sexual health surveys [PDF]

open access: yes, 2015
Background: Findings on the demographic and sexual health characteristics associated with the experience of a crisis pregnancy is important to inform the public health policy of a country, including Ireland.
AO Tsui   +36 more
core   +2 more sources

Oxytocin Effects on Food Stimulus Processing and Food Intake in Females With or Without Binge Eating Disorder

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Binge eating disorder (BED) is maintained by increased food‐related incentive salience, which is reflected by an attentional bias for food. Oxytocin acutely attenuates this bias in patients with anorexia nervosa and reduces food intake in males with normal or increased body weight.
Julia Nannt   +6 more
wiley   +1 more source

Relationship between Knowledge, Attitude and Behavior of Postnatal Woman Toward Participation in Permanent Contraception

open access: yesIndonesian Journal of Obstetrics and Gynecology, 2018
Objective: To investigate the association between knowledge, attitude, and behavior towards participation in permanent contraception and describe factors that could affect participation of permanent contraception in women in RSMH Palembang. Methods: This
Jhon Heriansyah   +3 more
doaj   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli   +17 more
wiley   +1 more source

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