Results 81 to 90 of about 329,488 (383)

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

Annals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek, David F. Hanff, Pim J. French, Sarah A. van Dijk, Erik A.C. Wiemer, Olivier C. Manintveld, Martin J. van den Bent, Walter Taal   +7 more
wiley   +1 more source

Use of Contraceptive among Postpartum Women of a Municipality: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association, 2021
Introduction: Contraception plays a key role in preventing unwanted births. It also decreases pregnancy and childbirth-related morbidities and mortalities, but many women don't use contraception particularly in the postpartum period.
Mukta Singh Bhandari, Suresh Kayastha
doaj   +1 more source

Adding It Up: Investing in Contraception and Maternal and Newborn Health, 2017—Estimation Methodology

, 2018
This report provides methodological details on the estimates presented in Adding It Up: Investing in Contraception and Maternal and Newborn Health, 2017 and related publications, and includes detailed national and regional data.
J. Darroch
semanticscholar   +1 more source

Previous reproductive history and post-natal family planning among HIV-infected women in Ukraine [PDF]

, 2010
BACKGROUND: Ukraine has the highest antenatal HIV prevalence in Europe. The national prevention of mother-to-child transmission (MTCT) programme has reduced the MTCT rate, but less attention has been given to the prevention of unintended pregnancy among ...
Boily, C. Thorne, Campbell, Corey, Delvaux, E. Kulakovskaya, Floridia, Gottlieb, Heard, I. Adejnova, I. Semenenko, J. Saxton, Kruglov, L. Kvasha, Mogilevkina, Mogilevkina, Mwapasa, Ostergren, Perlman, Popov, R. Malyuta, R. Tereshenko, Radestad, Rutenberg, Sanders, Sheth, Stanwood, Stringer, T. Pilipenko, Thorne, Thorne, van Brummen, Vikhlyaeva   +32 more
core   +2 more sources

Contraceptive counseling and postpartum contraceptive use [PDF]

American Journal of Obstetrics and Gynecology, 2015
The objective of the study was to examine the associations between prenatal and postpartum contraceptive counseling and postpartum contraceptive use.The Pregnancy Risk Assessment Monitoring System 2004-2008 data were analyzed from Missouri, New York state, and New York City (n = 9536).
Denise J. Jamieson, Lauren B. Zapata, Polly A. Marchbanks, Cheryl L. Robbins, Sarah Murtaza, Maura K. Whiteman, Kathryn M. Curtis, Denise V. D’Angelo   +7 more
openaire   +3 more sources

Neck‐vein thrombosis during spaceflight

British Journal of Clinical Pharmacology, EarlyView.
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley   +1 more source

Discovery of the Postcoital Contraceptive Effect of Rhus pentaphylla in a Study of Acute, Subchronic, and Neurodevelopmental Toxicity of Ethanolic Leaf Extract

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the present study, the acute, subchronic, and neurodevelopmental toxicity of Rhus pentaphylla, a Moroccan medicinal plant, was investigated in Swiss albino mice. HPLC analysis showed the presence of phenolic compounds with rutin as the principal component.
Fatimazahra Agouram, Aicha Ezoubeiri, Abderrahman Chait, Stefania Garzoli, Zahra Sokar   +4 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source

Long-acting reversible contraception use among residents in obstetrics/gynecology training programs [PDF]

, 2017
Background: The objective of the study was to estimate the personal usage of long-acting reversible contraception (LARC) among obstetrics and gynecology (Ob/Gyn) residents in the United States and compare usage between programs with and without a Ryan
Maddipati, Ragini, McNicholas, Colleen, Peipert, Jeffrey F, Zhao, Qiuhong, Zigler, Rachel E   +4 more
core   +2 more sources

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman, Liu Yuan, Sun Ying, Wang Yiyun   +3 more
wiley   +1 more source