Results 101 to 110 of about 22,954 (265)

Prescribing of Medication to Prevent Glucocorticoid Harms in Patients With Polymyalgia Rheumatica: A Cross‐Sectional Study and Two Emulated Target Trials in the Clinical Practice Research Datalink Aurum

Arthritis &Rheumatology, EarlyView.
Objective Polymyalgia rheumatica (PMR) is a common indication for long‐term glucocorticoid (GC) treatment. Bone‐protective and gastroprotective medications are recommended for those at high risk of adverse events from GCs, but no trials have evaluated their effectiveness in PMR.
Helen Twohig, David Jenkinson, James Bailey, Samantha Hider, Ian C. Scott, Sara Muller   +5 more
wiley   +1 more source

Percepção Bioética dos Enfermeiros na Administração e/ou Orientação do Uso do Contraceptivo de Emergência

Brazilian Journal of Forensic Sciences, Medical Law and Bioethics, 2019
A contracepção de emergência é envolta de polêmicas e ligada a assuntos como o aborto, planejamento familiar e gravidez na adolescência. A percepção do enfermeiro na administração e/ou orientação do contraceptivo de emergência é motivada pela ética ...
Anna Paula Rodrigues de Oliveira, Lígia Moura Burci   +1 more
doaj  

Efficacy and Safety of Nanoencapsulated Sirolimus plus Pegadricase: Results from the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, Accepted Article.
Objective DISSOLVE I and II examined efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP ...
Herbert S.B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

Sexual and Reproductive Healthcare Among Youth With Autism and ADHD: A Population‐Based Study From Sweden

Autism Research, EarlyView.
ABSTRACT Youth with autism spectrum disorder or attention‐deficit/hyperactivity disorder (ADHD) may face barriers to sexual and reproductive health (SRH) services. Yet, data on preventive SRH service use remain limited, especially digital care. This population‐based registry study investigated whether patterns of SRH service use differed by digital ...
Lovisa Hellsten, Jessica Rast, Anna Nielsen, Anna Mia Ekström, Kristina Gemzell‐Danielsson, Kyriaki Kosidou, Viktor H. Ahlqvist   +6 more
wiley   +1 more source

Clinical behavior of a cohort of adult women with facial acne treated with combined oral contraceptive: ethinylestradiol 20 µg/dienogest 2 mg

International Journal of Women's Health, 2017
John Palacio-Cardona,1 Diana María Caicedo Borrero2 1Student Welfare Service – Health Area, Santiago de Cali University, 2Support for Research, Academic, Scientific and Technological Services (SEACIT), Cali, Colombia Abstract: Acne ...
Palacio-Cardona J, Caicedo Borrero DM
doaj  

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Evaluation of pharmacokinetic interactions between long-acting cabotegravir or emtricitabine/tenofovir disoproxil fumarate and hormonal contraceptive agents: a tertiary analysis of South African participants in HPTN 084. [PDF]

J Int AIDS Soc
Marzinke MA, Hanscom B, Haines D, Scarsi KK, Agyei Y, Piwowar-Manning E, Hendrix CW, Gollings R, Rose S, Mathew C, Panchia R, Spooner E, Singh N, Bock P, Rinehart AR, Ford SL, Rooney JF, Soto-Torres L, Cohen MS, Hosseinipour MC, Delany-Moretlwe S, HPTN 084 Study Team.   +21 more
europepmc   +1 more source

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Physiologically-based pharmacokinetic modeling of prominent oral contraceptive agents and applications in drug-drug interactions. [PDF]

CPT Pharmacometrics Syst Pharmacol
Lewis GJ, Ahire D, Taskar KS.
europepmc   +1 more source