Results 251 to 260 of about 254,999 (359)

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing <i>TNNT2</i> sarcomeric variants. [PDF]

iScience
Coscarella IL, Usman OH, Wang L, Landim-Vieira M, Wirstiuk L, Brown AN, Zorio DAR, Washburn BK, Vied C, Knollmann BC, Solís C, Galkin VE, Chase PB, Hinson JT, Irianto J, Pinto JR.   +15 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Nonmuscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling. [PDF]

Circ Res
Hayes JB, Choudhary D, Ritter D, Neininger-Castro AC, Willet AH, Caplan LR, Wang Y, Liu X, Taneja N, Sanchez ZC, Smart K, Armstrong DWJ, Reinhart-King CA, Liu Q, Tyska MJ, Tabdanov ED, Merryman WD, Wells QS, Knapik EW, Burnette DT.   +19 more
europepmc   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Pathophysiology and management of right ventricular failure in critically ill patients: A narrative review. [PDF]

World J Crit Care Med
Kermanian R, Dosanjh H, Lewis MI, Matusov Y.   +3 more
europepmc   +1 more source

Contractile System [PDF]

, 2020
openaire   +1 more source

Author response: TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

Christopher N. Rudzitis, Mónika Lakk, Ayushi Singh, Sarah N. Redmon, Denisa Kirdajova, Yun‐Ting Tseng, Michael L. De Ieso, W. Daniel Stamer, Samuel Herberg, David Križaj   +9 more
openalex   +1 more source

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

TPM2 regulates contractility and biomechanical properties in trabecular meshwork cells. [PDF]

Sci Rep
Shen B, Gong Y, Xu Y, Ling Q, Huang R, Jia X.   +5 more
europepmc   +1 more source