Results 31 to 40 of about 4,645 (267)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A data decomposition-based hierarchical classification method for multi-label classification of contractual obligations for the purpose of their governance

Scientific Reports
Contract governance ensures that the agreed outcomes between customers and vendors are fulfilled. Information Technology (IT) outsourcing organizations enter thousands of contractual relationships each month leading to a high volume of business-critical ...
Amrita Singh, Preethu Rose Anish, Aparna Verma, Sivanthy Venkatesan, Logamurugan V, Smita Ghaisas   +5 more
doaj   +1 more source

Managerial control: a study among public/private relations from the perspective of transaction cost theory

Revista Ambiente Contábil
Purpose: The present study investigated contractual characteristics and management control mechanisms in public contracts for assignment of use in a Military Organization (MO) of the Brazilian Army, and characterized the transactions object of the ...
Júlio Ricardo Rezende da Costa, Karla Katiuscia Nóbrega de Almeida   +1 more
doaj   +1 more source

The Evolution of Contractual and Relational Governance in IS Outsourcing [PDF]

SSRN Electronic Journal, 2012
This paper explores how and why contractual and relational governance evolve over time in information systems (IS) outsourcing projects. Governance is broken down into its foundation and action dimension resulting in four governance parameters: trust /norms and informal control representing relational governance; contract and formal control reflecting ...
Fischer, Thomas, Huber, Thomas, Dibbern, Jens, Hirschheim, Rudolf   +3 more
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The incentive effects of project governance elements on agents in agent-led construction of social security housing projects

International Journal of Strategic Property Management
The agent-led construction system is a construction mode that emphasizes the introduction of professional management teams instead of government departments to develop public projects in China, including social security housing.
Zhiqi Chen, Liming Yao, Minghui Zheng, Ling Zhang   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

An Innovation Ecosystem Game Study: The Role of Noncontractual Mechanisms

Journal of Mathematics, 2023
Innovation ecosystem management is now a new paradigm in innovation management research. Innovation ecosystems are dynamic innovation alliances based on noncontractual governance.
Ying Gao, Zihan Zhu, Fulei Shi
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source