Advanced Science, EarlyView.Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
A full formal representation of Arrow's impossibility theorem. [PDF]
PLoS OneYamamoto K.
europepmc +1 more source
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source
Boolean network and meshless simulations for the comparison of transport and reaction mechanisms arising in one-short tri-exponential and uniform infusion electrochemotherapeutic treatments. [PDF]
Front BioinformVélez Salazar FM +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño +5 more
wiley +1 more source
Structural Design of a Nanogel Reaction Device with Emphasis on Temperature-Field Uniformity. [PDF]
Materials (Basel)Tang Z +6 more
europepmc +1 more source
Rotation of Crystal Seed During Early Stages of Growth Reveals the Anisotropy of Glass Matrix
Advanced Science, EarlyView.Molecular dynamics simulations reveal that crystal seeds can spontaneously rotate within glass at high temperatures due to anisotropic forces at the glass‐crystal interface. This rotation challenges the long‐held view of glass as an isotropic solid and highlights how atomic‐scale inhomogeneities can influence crystal growth and microstructure of LiNbO3‐
R. Thapa +4 more
wiley +1 more source
A dialectical lens for AI and medical humanities: advancing responsible augmented humanism in Digital Public Health. [PDF]
Front Public HealthChen S, Peng Z, Liu N.
europepmc +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Exploring the future of the diagnostic process in primary care : The value of making contradictions explicit using change lab methodology with healthcare professionals and patients. [PDF]
BMC Health Serv ResVaes EWP +6 more
europepmc +1 more source