Results 41 to 50 of about 188,355 (251)

Contradictions of the digital economy: challenges and directions of resolution

Векторы благополучия: экономика и социум
The digital economy has become an integral part of the modern world, bringing new opportunities and causing contradictions in its development. In recent decades, there has been a rapid growth in information and communication technologies, which have ...
A.O. Uzhegov, O.K. Tikhonova
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Are there inherent contradictions in attempting to implement education for sustainable development in schools?

Despite being ranked according to narrow measures of pupil achievement, many schools aim to become more sustainable. Faced with indicators suggesting the rapid degradation of social-ecological systems, these schools would prefer not to be part of the ...
Vare, Paul
core   +3 more sources

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Resolving Contradictions in Public Policies on Child Begging: An N- Alectic Approach [PDF]

Neutrosophic Sets and Systems
This project fills a wicked problem gap with policy assessments relative to child begging—a condition that keeps children in a vulnerable state within the confines of the urban setting—and the literature gap exists because while prior researchers aimed ...
Esther Maricela Coello Avilés, Kevin Luis Flores Vega, Keyla Nayely Casquete Cedeño   +2 more
doaj   +1 more source

La crise des intellectuels et ses avatars dans Les Mandarins de Simone de Beauvoir

Acta Universitatis Lodziensis: Folia Litteraria Romanica, 2022
À travers Les Mandarins, Simone de Beauvoir met en scène la crise qui touche les milieux intellectuels français derrière des personnages d’écrivains aux prises avec les dilemmes idéologiques et politiques de l’après-guerre. Ces personnages, réfléchissant
Anna Ledwina
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Imagined, Real and Moral Economies

Culture Unbound: Journal of Current Cultural Research, 2014
This article explores three different inflections of the idea of economy: imagined, real and moral. Each offers a distinctive way of thinking about economies and each raises the possibility of providing critical purchase on the formations of ’actually ...
John Clarke
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source