Results 101 to 110 of about 448,489 (363)

Innovative insights into the effects of a high‐sucrose diet on pancreatic health and the therapeutic role of empagliflozin in type 2 diabetes: An experimental study

Animal Models and Experimental Medicine, EarlyView.
Histologic assessment of pancreatic tissues using the H&E method (Scale bar = 100 μm. Images were captured at 400×). A high‐sucrose diet induced structural damage in pancreatic tissue, whereas empagliflozin treatment markedly improved these histological alterations.
Emad Gholami, Ali Fardin, Fazeleh Iranshahi, Alireza Malek, Ali Saravani, Faranaz Aghvami, Houman Parsaei, Habib Yaribeygi   +7 more
wiley   +1 more source

Quercetin, a Promising Clinical Candidate for The Prevention of Contrast-Induced Nephropathy

International Journal of Molecular Sciences, 2019
Iodinated contrast media (CM) are the leading cause of acute renal failure of toxic origin. Between 21% and 50% of patients that receive them develop contrast-induced nephropathy (CIN).
Laura Vicente-Vicente, D. González-Calle, Alfredo G. Casanova, M. Hernández-Sánchez, M. Prieto, J. C. Rama-Merchán, J. Martín‐Moreiras, F. Martín-Herrero, P. Sánchez, F. López-Hernández, I. Cruz-González, A. Morales   +11 more
semanticscholar   +1 more source

Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]

, 2013
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Burhan, I, Funck, M, Huang, L, Johnson, TS, Scarpellini, A, Schroeder, N, Verderio, EAM   +6 more
core   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Cystatin C and contrast-induced nephropathy [PDF]

Nephrology Dialysis Transplantation, 2008
Sir, The paper by Kimmel et al. [1] concludes that cystatin C blood level variations are a more reliable parameter than serum creatinine increments for the diagnosis of contrastinduced nephropathy (CIN). However, this conclusion does not seem sufficiently supported by the data to us.
GAMBARO, Giovanni, Maria Stella Graziani, RIBICHINI, Flavio Luciano   +2 more
openaire   +3 more sources

Contrast-induced acute kidney injury and renal support for acute kidney injury : a KDIGO summary (part 2) [PDF]

, 2013
Acute kidney injury (AKI) is a common and serious problem affecting millions and causing death and disability for many. In 2012, Kidney Disease: Improving Global Outcomes completed the first ever international multidisciplinary clinical practice ...
Kellum, John A, Lameire, Norbert
core   +2 more sources

Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers

British Journal of Clinical Pharmacology, EarlyView.
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics (CPT) exams, comparing their results to medical students and exploring their ability to identify poorly formulated
Alexandre O. Gérard, Diane Merino, Marc Labriffe, Fanny Rocher, Delphine Viard, Laurence Zemori, Thibaud Lavrut, Erik M. Donker, Joost D. Piët, Jean‐Paul Fournier, Milou‐Daniel Drici, Alexandre Destere   +11 more
wiley   +1 more source

THE RATE OF RENAL DYSFUNCTION IN PATIENTS WITH ACUTE CORONARY SYNDROME AFTER USING X-RAY CONTRAST AGENTS

Медицинский вестник Юга России, 2015
Purpose: to evaluate the rate and severity of filtration renal dysfunction in patients with acute coronary syndrome after percutaneous coronary intervention (PCI) with X-ray contrast.Materials and Methods: serum creatinine levels were collected from 71 ...
N. T. Vatutin, M. I. Zinkovych
doaj   +1 more source

Prophylaxis Strategies for Contrast-Induced Nephropathy [PDF]

JAMA, 2006
Contrast-induced nephropathy is associated with significant economic and clinical consequences, including prolonged hospitalization, the requirement for dialysis, and an increased risk of death.To summarize the current state of evidence for prophylaxis of contrast-induced nephropathy, provide evidence-based recommendations regarding management of high ...
Neesh Pannu, Natasha Wiebe, Marcello Tonelli, for the Alberta Kidney Disease Network   +3 more
openaire   +2 more sources

Urine metabolomic analysis to detect metabolites associated with the development of contrast induced nephropathy. [PDF]

, 2016
ObjectiveContrast induced nephropathy (CIN) is a result of injury to the proximal tubules. The incidence of CIN is around 11% for imaging done in the acute care setting.
Diercks, Deborah B, Kline, Jeffrey A, Owen, Kelly P, Sutter, Mark E   +3 more
core   +1 more source